{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:55:51Z","timestamp":1791165351317,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The management of patients with atrial fibrillation (AF) and malignancy is challenging given the paucity of evidence supporting their appropriate clinical management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the outcomes of patients with active or prior malignancy in a contemporary cohort of European AF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients enrolled in the EURObservational Research Programme in AF General Long\u2010Term Registry were categorized into 3 categories: No Malignancy (NoMal), Prior Malignancy (PriorMal) and Active Malignancy (ActiveMal). The primary outcomes were all\u2010cause death and the composite outcome MACE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10 383 patients were analysed. Of these, 9597 (92.4%) were NoMal patients, 577 (5.6%) PriorMal and 209 (2%) ActiveMal. Lack of any antithrombotic treatment was more prevalent in ActiveMal patients (12.4%) as compared to other groups (5.0% vs 6.3% for PriorMal and NoMal, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). After a median follow\u2010up of 730\u00a0days, there were 982 (9.5%) deaths and 950 (9.7%) MACE events. ActiveMal was independently associated with a higher risk for all\u2010cause death (HR 2.90, 95% CI 2.23\u20133.76) and MACE (HR 1.54, 95% CI 1.03\u20132.31), as well as any haemorrhagic events and major bleeding (OR 2.42, 95% CI 1.49\u20133.91 and OR 4.18, 95% CI 2.49\u20137.01, respectively). Use of oral anticoagulants was not significantly associated with a higher risk for all\u2010cause death or bleeding in ActiveMal patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a large contemporary cohort of AF patients, active malignancy was independently associated with all\u2010cause death, MACE and haemorrhagic events. Use of anticoagulants was not associated with a higher risk of all\u2010cause death in patients with active malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13773","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T13:29:28Z","timestamp":1647696568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of malignancy on outcomes in European patients with atrial fibrillation: A report from the ESC\u2010EHRA EURObservational research programme in atrial fibrillation general long\u2010term registry"],"prefix":"10.1111","volume":"52","author":[{"given":"Vincenzo L.","family":"Malavasi","sequence":"first","affiliation":[{"name":"Cardiology Division Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia Policlinico di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vitolo","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia Policlinico di Modena  Modena Italy"},{"name":"Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart &amp; Chest Hospital  Liverpool UK"},{"name":"Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1452-2478","authenticated-orcid":false,"given":"Marco","family":"Proietti","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart &amp; Chest Hospital  Liverpool UK"},{"name":"Department of Clinical Sciences and Community Health University of Milan  Milan Italy"},{"name":"Geriatric Unit IRCCS Istituti Clinici Scientifici Maugeri  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Diemberger","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine Institute of Cardiology University of Bologna Policlinico S. Orsola\u2010Malpighi  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Fauchier","sequence":"additional","affiliation":[{"name":"Service de Cardiologie Centre Hospitalier Universitaire Trousseau  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Marin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Virgen de la Arrixaca IMIB\u2010Arrixaca University of Murcia CIBERCV  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nabauer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ludwig\u2010Maximilians\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana S.","family":"Potpara","sequence":"additional","affiliation":[{"name":"School of Medicine University of Belgrade  Belgrade Serbia"},{"name":"Intensive Arrhythmia Care Cardiology Clinic Clinical Center of Serbia  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheorghe\u2010Andrei","family":"Dan","sequence":"additional","affiliation":[{"name":"\u2018Carol Davila\u2019 University of Medicine Colentina University Hospital  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Kalarus","sequence":"additional","affiliation":[{"name":"Department of Cardiology SMDZ in Zabrze Medical University of Silesia  Katowice Poland"},{"name":"Silesian Centre for Heart Diseases  Zabrze Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tavazzi","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research  Cotignola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-6779","authenticated-orcid":false,"given":"Aldo Pietro","family":"Maggioni","sequence":"additional","affiliation":[{"name":"ANMCO Research Center  Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre A.","family":"Lane","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart &amp; Chest Hospital  Liverpool UK"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. 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