{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:48:21Z","timestamp":1760986101327,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100018573","name":"Istanbul Medeniyet University","doi-asserted-by":"publisher","award":["1358"],"award-info":[{"award-number":["1358"]}],"id":[{"id":"10.13039\/100018573","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019 global pandemic started in late 2019 with the first wave. In this cross\u2010sectional and observational study, we evaluated the associations between the biomarkers, COVID\u201019 pneumonia severity and 1\u2010year mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A sample of 276 polymerase chain reaction (PCR)\u2010positive patients for SARS\u2010CoV\u20102 was included. Computerized tomography severity score (CT\u2010SS) was used to assess the severity of COVID\u201019 pneumonia in 222 cases. Multivariate analyses were performed to find the predictors of CT\u2010SS, severe CT\u2010SS (\u226520) and 1\u2010year mortality. Biomarkers of ferritin, high\u2010sensitive C\u2010reactive protein (CRP), lactate dehydrogenase (LDH), cardiac troponin (cTn), neutrophil\u2010to\u2010lymphocyte ratio (NLR), uric acid (UA) and <jats:sc>d<\/jats:sc>\u2010dimer were routinely measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Severe CT\u2010SS (&gt;20) was observed in 86 (31.2%) cases. Mortality was observed in 75 (27.2%) patients at 1 year. LDH displayed the highest predictive accuracy for severe CT\u2010SS (AUC 0.741, sensitivity\u00a0=\u00a081% and specificity\u00a0=\u00a068%, cut\u2010off value: 360\u2009mg\/dl). Linear regression analysis displayed that LDH predicted CT\u2010SS [B\u00a0=\u00a011 (95% CI for B\u00a0=\u00a05\u201317, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001)]. Age was the most significant parameter that was associated with severe CT\u2010SS (OR 0.96, 95% CI 0.92\u20130.99, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.015). <jats:sc>d<\/jats:sc>\u2010dimer was the only biomarker that predicted with 1\u2010year mortality (OR 1.62, 95% CI 1.08\u20132.42, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LDH is a sensitive and specific biomarker to determine patients with severe lung injury in COVID\u201019. <jats:sc>d<\/jats:sc>\u2010dimer is the only biomarker that predicts 1\u2010year mortality. Neither LDH nor CT\u2010SS is associated with 1\u2010year mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13827","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T17:33:56Z","timestamp":1656264836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Discrepancy between biomarkers of lung injury and 1\u2010year mortality in <scp>COVID<\/scp>\u201019"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3318-3555","authenticated-orcid":false,"given":"Basak","family":"Atalay","sequence":"first","affiliation":[{"name":"Department of Radiology School of Medicine, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital  Istanbul 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