{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T03:22:34Z","timestamp":1776482554402,"version":"3.51.2"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007496","name":"Fondazione Cassa di Risparmio di Genova e Imperia","doi-asserted-by":"publisher","award":["\u201cStronger, less frail\u201d GRANT 2018"],"award-info":[{"award-number":["\u201cStronger, less frail\u201d GRANT 2018"]}],"id":[{"id":"10.13039\/501100007496","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Frailty has been recognized as potential surrogate of biological age and relevant risk factor for COVID\u201019 severity. Thus, it is important to explore the frailty trajectories during COVID\u201019 pandemic and understand how COVID\u201019 directly and indirectly impacts on frailty condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 217 community\u2010dwelling older adults with available information on frailty condition as assessed by multidimensional frailty model both at baseline and at one\u2010year follow\u2010up using Multidimensional Prognostic Index (MPI) tools. Pre\u2010frail\/frail subjects were identified at baseline as those with MPI score\u2009&gt;0.33 (MPI grades 2\u20133). Frailty worsening was defined by MPI difference between 12\u2009months follow\u2010up and baseline \u22650.1. Multivariable logistic regression was modelled to identify predictors of worsening of frailty condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Frailer subjects at baseline (MPI grades 2\u20133\u00a0=\u00a048.4%) were older, more frequently female and had higher rates of hospitalization and Sars\u2010CoV\u20102 infection compared to robust ones (MPI grade 1). Having MPI grades 2\u20133 at baseline was associated with higher risk of further worsening of frailty condition (adjusted odd ratio (aOR): 13.60, 95% confidence interval (CI): 4.01\u201346.09), independently by age, gender and Sars\u2010CoV\u20102 infection. Specifically, frail subjects without COVID\u201019 (aOR: 14.84, 95% CI: 4.26\u201351.74) as well as those with COVID\u201019 (aOR: 12.77, 95% CI: 2.66\u201361.40, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) had significantly higher risk of worsening of frailty condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Effects of COVID\u201019 pandemic among community\u2010dwelling frailer individuals are far beyond the mere infection and disease, determining a significant deterioration of frailty status both in infected and non\u2010infected subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13838","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T08:18:22Z","timestamp":1658045902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Frailty trajectories in community\u2010dwelling older adults during <scp>COVID<\/scp>\u201019 pandemic: The <scp>PRESTIGE<\/scp> study"],"prefix":"10.1111","volume":"52","author":[{"given":"Alberto","family":"Pilotto","sequence":"first","affiliation":[{"name":"Geriatrics Unit, Department of Geriatric Care Orthogeriatrics and Rehabilitation  Genoa Italy"},{"name":"Department of Interdisciplinary Medicine, Clinica Medica e Geriatria \u201cCesare Frugoni\u201d University of Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1549-6451","authenticated-orcid":false,"given":"Carlo","family":"Custodero","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, Clinica Medica e Geriatria \u201cCesare Frugoni\u201d University of Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Zora","sequence":"additional","affiliation":[{"name":"Geriatrics Unit, Department of Geriatric Care Orthogeriatrics and Rehabilitation  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