{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:31Z","timestamp":1787014111459,"version":"build-2736575974"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERCV CB16\/11\/00411 to LB, TERCEL RD16\/0011\/018"],"award-info":[{"award-number":["CIBERCV CB16\/11\/00411 to LB, TERCEL RD16\/0011\/018"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009664","name":"Sociedad Espa\u00f1ola de Cardiolog\u00eda","doi-asserted-by":"publisher","award":["FEC 2019 to MBP and FEC 2020 to GV"],"award-info":[{"award-number":["FEC 2019 to MBP and FEC 2020 to GV"]}],"id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We performed a comprehensive assessment of the effect of myocardial ischemia duration on cardiac structural and functional parameters by serial cardiac magnetic resonance (CMR) and characterized the evolving scar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CMR follow\u2010up on the cardiac impact of time of ischemia in a closed\u2010chest animal model of myocardial infarction with human resemblance is missing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pigs underwent MI induction by occlusion of the left anterior descending (LAD) coronary artery for 30, 60, 90 or 120\u2009min and then revascularized. Serial CMR was performed on day 3 and day 42 post\u2010MI. CMR measurements were also run in a sham\u2010operated group. Cellular and molecular changes were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On day 3, cardiac damage and function were similar in sham and pigs subjected to 30\u2009min of ischemia. Cardiac damage (oedema and necrosis) significantly increased from 60\u2009min onwards. Microvascular obstruction was extensively seen in animals with \u226590\u2009min of ischemia and correlated with cardiac damage. A drop in global systolic function and wall motion of the jeopardized segments was seen in pigs subjected to \u226560\u2009min of ischemia. On day 42, scar size and cardiac dysfunction followed the same pattern in the animals subjected to \u226560\u2009min of ischemia. Adverse left ventricular remodelling (worsening of both LV volumes) was only present in animals subjected to 120\u2009min of ischemia. Cardiac fibrosis, myocyte hypertrophy and vessel rarefaction were similar in the infarcted myocardium of pigs subjected to \u226560\u2009min of ischemia. No changes were observed in the remote myocardium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sixty\u2010minute LAD coronary occlusion already induces cardiac structural and functional alterations with longer ischemic time (120\u2009min) causing adverse LV remodelling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.13860","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T10:44:32Z","timestamp":1660992272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A comprehensive and longitudinal cardiac magnetic resonance imaging study of the impact of coronary ischemia duration on myocardial damage in a highly translatable animal model"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-4150","authenticated-orcid":false,"given":"Monika","family":"Radike","sequence":"first","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Radiology Department Liverpool Heart and Chest Hospital NHS Foundation Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Sutelman","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-5883","authenticated-orcid":false,"given":"Soumaya","family":"Ben\u2010Aicha","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7362-4330","authenticated-orcid":false,"given":"Manuel","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Radiology Department Liverpool Heart and Chest Hospital NHS Foundation Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiomar","family":"Mendieta","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e0","family":"Alcover","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Casan\u00ed","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Arderiu","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1759-9756","authenticated-orcid":false,"given":"Mar\u00eda","family":"Borrell\u2010Pages","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-954X","authenticated-orcid":false,"given":"Teresa","family":"Padr\u00f3","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"CiberCV Institute Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-2459","authenticated-orcid":false,"given":"Lina","family":"Badimon","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"CiberCV Institute Carlos III  Madrid Spain"},{"name":"Cardiovascular Research Chair UAB  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-8873","authenticated-orcid":false,"given":"Gemma","family":"Vilahur","sequence":"additional","affiliation":[{"name":"Cardiovascular Program\u2010ICCC Research Institute Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"CiberCV Institute Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.7.1923"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121424.76486.20"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0588-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0673-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0660-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.01.042"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0760-z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00884-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.679639"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.086"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0509-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030785"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab370"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00893-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.002"},{"issue":"5","key":"e_1_2_8_17_1","first-page":"432","article-title":"A comparative anatomic and physiologic overview of the porcine heart","volume":"53","author":"Lelovas PP","year":"2014","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/26.2.170"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.53.1092"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90102-I"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-01995-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.05.024"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006774"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.069"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.02.028"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx414"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.12.012"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000411"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy201"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.05.020"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.01.014"},{"issue":"9","key":"e_1_2_8_32_1","first-page":"826","article-title":"Reliability of cardiac magnetic resonance imaging indicators of myocardial viability for predicting the recovery of systolic function after a first acute myocardial infarction with a patent culprit artery","volume":"57","author":"L\u00f3pez Lereu MP","year":"2004","journal-title":"Rev Esp Cardiol"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.12.021"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313947"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0403-y"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044176"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0696-8"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy253"},{"issue":"5","key":"e_1_2_8_39_1","first-page":"H1812","article-title":"Innate protection of baboon myocardium: effects of coronary artery occlusion and reperfusion","volume":"270","author":"Shen YT","year":"1996","journal-title":"Am J Phys"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00877317"},{"issue":"2","key":"e_1_2_8_41_1","first-page":"I8","article-title":"Studies of experimental coronary artery reperfusion. Effects on infarct size, myocardial function, biochemistry, ultrastructure and microvascular damage","volume":"68","author":"Kloner RA","year":"1983","journal-title":"Circulation"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/21.9.668"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060350"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-11-38"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.07.039"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310820"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-9912-2-22"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315344"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.01.008"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025582"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.004"},{"issue":"5","key":"e_1_2_8_52_1","first-page":"V39","article-title":"The rapid evolution of a myocardial infarction in an end\u2010artery coronary preparation","volume":"76","author":"Horneffer PJ","year":"1987","journal-title":"Circulation"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00870-y"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00896-2"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0756-8"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.4.693"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.194"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5875-3"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-020-09975-3"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092190110"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00480-6"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy301"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0064"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14839"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14931"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.901"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14975"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.602497"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13860","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eci.13860","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T04:09:24Z","timestamp":1692504564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.13860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/eci.13860"],"URL":"https:\/\/doi.org\/10.1111\/eci.13860","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2022-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13860"}}