{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:28:57Z","timestamp":1777372137614,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GL1746D"],"award-info":[{"award-number":["01GL1746D"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As neonates are susceptible for many diseases, establishing noninvasive diagnostic methods is desirable. We hypothesized that volatile organic compounds (VOCs) could be successfully measured in diaper samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a feasibility study to investigate whether ambient air\u2010independent headspace measurements of the VOC profiles of diapers from premature infants can be conducted using ion mobility spectrometer coupled with multi\u2010capillary columns (B &amp; S Analytik GmbH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analysed 39 diapers filled with stool (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) or urine (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) respectively, using empty diapers as a control (<jats:italic>n<\/jats:italic>\u00a0=\u00a09). A total of 158 different VOCs were identified, and we classified the content of the diapers (urine or stool) according to their VOC profiles with a significance level of <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have developed a novel method to study headspace VOC profiles of biosamples using ion mobility spectrometry coupled with multi\u2010capillary columns. Using this method, we have characterized the VOC profiles of stool and urine of preterm neonates. Future studies are warranted to characterize specific VOC profiles in infections and other diseases of the preterm neonate, thus establishing quick and noninvasive diagnostics in the routine care of the highly vulnerable preterm and term neonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13868","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T12:00:29Z","timestamp":1662379229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patterns of volatile organic compounds in excrements of preterm neonates"],"prefix":"10.1111","volume":"53","author":[{"given":"Michelle","family":"Bous","sequence":"first","affiliation":[{"name":"Department of General Pediatrics and Neonatology Saarland University Medical School  Homburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erol","family":"Tutdibi","sequence":"additional","affiliation":[{"name":"Department of General 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