{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T07:13:30Z","timestamp":1780816410355,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007268","name":"Washington University in St. Louis","doi-asserted-by":"publisher","award":["12\u20103271\u2010 93128"],"award-info":[{"award-number":["12\u20103271\u2010 93128"]}],"id":[{"id":"10.13039\/100007268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study is to evaluate whether post\u2010acute sequelae of COVID\u201019 cardiovascular syndrome (PASC\u2010CVS) is associated with alterations in coronary circulatory function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In individuals with PASC\u2010CVS but without known cardiovascular risk factors (<jats:italic>n<\/jats:italic>\u00a0=\u00a023) and in healthy controls (CON, <jats:italic>n<\/jats:italic>\u00a0=\u00a023), myocardial blood flow (MBF) was assessed with <jats:sup>13<\/jats:sup>N\u2010ammonia and PET\/CT in mL\/g\/min during regadenoson\u2010stimulated hyperemia, at rest, and the global myocardial flow reserve (MFR) was calculated. MBF was also measured in the mid and mid\u2010distal myocardium of the left ventricle (LV). The \u0394 longitudinal MBF gradient (hyperemia minus rest) as a reflection of an impairment of flow\u2010mediated epicardial vasodilation, was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Resting MBF was significantly higher in PASC\u2010CVS than in CON (1.29\u2009\u00b1\u20090.27 vs. 1.08\u2009\u00b1\u20090.20\u2009ml\/g\/min, <jats:italic>p<\/jats:italic>\u2009\u2264\u2009.024), while hyperemic MBFs did not differ significantly among groups (2.46\u2009\u00b1\u20090.53 and 2.40\u2009\u00b1\u20090.34\u2009ml\/g\/min, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.621). The MFR was significantly less in PASC\u2010CVS than in CON (1.97\u2009\u00b1\u20090.54 vs. 2.27\u2009\u00b1\u20090.43, <jats:italic>p<\/jats:italic>\u2009\u2264\u2009.031). In addition, there was a \u0394 longitudinal MBF gradient in PASC\u2010CVS, not observed in CON (\u22120.17\u2009\u00b1\u20090.18 vs. 0.04\u2009\u00b1\u20090.11\u2009ml\/g\/min, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Post\u2010acute sequelae of COVID\u201019 cardiovascular syndrome may be associated with an impairment of flow\u2010mediated epicardial vasodilation, while reductions in coronary vasodilator capacity appear predominantly related to increases in resting flow in women deserving further investigations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13871","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T21:04:45Z","timestamp":1662757485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Post <scp>COVID<\/scp>\u201019 syndrome with impairment of <scp>flow\u2010mediated<\/scp> epicardial vasodilation and flow reserve"],"prefix":"10.1111","volume":"52","author":[{"given":"Amanda","family":"Verma","sequence":"first","affiliation":[{"name":"Division of Nuclear Medicine Mallinckrodt Institute of Radiology Washington University School of Medicine  St. Louis Missouri USA"},{"name":"Cardiovascular Division, John T. 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Milliken Department of Internal Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Upadhyaya","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Mallinckrodt Institute of Radiology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Valenta","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Mallinckrodt Institute of Radiology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Lyons","sequence":"additional","affiliation":[{"name":"Infectious Disease Division, John T. Milliken Department of Internal Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Marschall","sequence":"additional","affiliation":[{"name":"Infectious Disease Division, John T. 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