{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:34:26Z","timestamp":1772134466931,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T00:00:00Z","timestamp":1669420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Controversies on sub\u2010populations most sensitive to therapy and the best timing of starting the treatment still surround the use of immunomodulatory drugs in COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We designed a multicentre open\u2010label randomised controlled trial to test the effect of prompt adding of tofacitinib to standard therapy for hospitalised patients affected by mild\/moderate COVID\u201019 pneumonitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients admitted to three Italian hospitals affected by COVID\u201019 pneumonitis not requiring mechanical ventilation were randomised to receive standard treatment alone or tofacitinib (10\u00a0mg\/bid) for 2\u2009weeks, starting within the first 24\u2009h from admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 116 patients were randomised; 49 in the experimental arm completed the 14\u2010day treatment period, 9 discontinued tofacitinib as the disease worsened and were included in the analysis, and 1 died of respiratory failure. All 58 control patients completed the study. Clinical and demographic characteristics were similar between the study groups. In the tofacitinib group, 9\/58 (15.5%) patients progressed to noninvasive ventilation (CPAP) to maintain SO<jats:sub>2<\/jats:sub>\u2009&gt;\u200993%, invasive mechanical ventilation or death by day 14 was 15.5%, significantly less than in the control group (20\/58, 34.4%, RR 0,45, RRR \u221255%, NNT 5; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.018). No differences in severe adverse effect incidence had been observed across the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010dose tofacitinib therapy in patients with COVID pneumonitis is safe and may prevent deterioration to respiratory failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13898","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T07:17:58Z","timestamp":1668583078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early administration of tofacitinib in <scp>COVID<\/scp>\u201019 pneumonitis: An open randomised controlled trial"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5841-2302","authenticated-orcid":false,"given":"Alessia","family":"Ferrarini","sequence":"first","affiliation":[{"name":"Clinica Medica Ospedali Riuniti di Ancona  Ancona Italy"},{"name":"Gastroenterologia ed Endoscopia Digestiva Ospedali Riuniti Marche Nord  Fano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Vacca","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Oncologia Umana U.O.C Medicina Interna Universitaria \u201cG. Baccelli\u201d A.O.U.C, Policlinico di Bari  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-9698","authenticated-orcid":false,"given":"Antonio Giovanni","family":"Solimando","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Oncologia Umana U.O.C Medicina Interna Universitaria \u201cG. Baccelli\u201d A.O.U.C, Policlinico di Bari  Bari Italy"},{"name":"IRCCS Istituto Tumori \u201cGiovanni Paolo II\u201d Bari  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Tavio","sequence":"additional","affiliation":[{"name":"Malattie Infettive Ospedali Riuniti di Ancona  Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Acquaviva","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Oncologia Umana U.O.C Medicina Interna Universitaria \u201cG. 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