{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:30:40Z","timestamp":1792071040171,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00570"],"award-info":[{"award-number":["PI19\/00570"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alzheimer's disease (AD) is a complex disease that shares clinical features with other dementias. It is important to establish a specific and reliable diagnosis. Nowadays, AD diagnosis is based on cerebrospinal fluid (CSF) biomarkers. However, the corresponding cut\u2010offs differ amongst studies. This study aims to evaluate the CSF biomarkers in the AD differential diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical relevant biomarkers (amyloid \u03b242 (A\u03b242), t\u2010Tau, p\u2010Tau, amyloid \u03b240 (A\u03b240), neurofilament light <jats:italic>chain<\/jats:italic> (<jats:italic>NfL<\/jats:italic>)) <jats:italic>were determined in CSF<\/jats:italic> samples from participants classified as AD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0124) and non\u2010AD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0148) patients from the Neurology Unit. They were included and evaluated consecutively (August 2018\u2013October 2020). The clinical utility of these biomarkers was evaluated by AUC\u2010ROC curves and the corresponding cut\u2010off points were defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed satisfactory accuracy (AUC\u2010ROC 0.91 for A\u03b242, 0.890 for t\u2010Tau and 0.933 for p\u2010Tau); whilst A\u03b240 and NfL did not show good discriminatory capacity (AUC\u2010ROC 0.557 and 0.738, respectively). The ratios A\u03b242\/A\u03b240 and t\u2010Tau\/A\u03b242 improved the diagnosis indices of each individual biomarker, with AUC\u2010ROC of 0.980 and 0.971, respectively. Also, elevated levels of NfL were found in the frontotemporal dementia group compared with the other participant groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ratio A\u03b242\/A\u03b240 showed the highest discriminating capacity between AD and non\u2010AD patients and might be useful in clinical practice. Regarding NfL, it is not a specific biomarker for AD; however, it might be helpful for the differential diagnosis of frontotemporal dementia. Nevertheless, further analysis in an external cohort is required in order to validate these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13910","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T16:18:46Z","timestamp":1668874726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical usefulness of cerebrospinal fluid biomarkers in Alzheimer's disease"],"prefix":"10.1111","volume":"53","author":[{"given":"Carmen","family":"Pe\u00f1a\u2010Bautista","sequence":"first","affiliation":[{"name":"Alzheimer Disease Research Group Instituto de Investigaci\u00f3n Sanitaria La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"\u00c1lvarez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Alzheimer Disease Research Group Instituto de Investigaci\u00f3n Sanitaria La Fe  Valencia 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