{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:03:54Z","timestamp":1783699434447,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The objective of this study was to assess the 10\u2010year prevalence of latent tuberculosis infection (LTBI) among Apulian patients with rheumatic diseases (RDs). Secondary endpoint was to record new cases of active TB disease and LTBI among patients treated with biologic disease\u2010modifying antirheumatic drugs (bDMARDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed the results from the patients included in the BIOPURE registry from 2009 to 2018, who underwent QuantiFERON\u2010TB Gold In\u2010tube (QFT\u2010GIT) test as screening before bDMARDs treatment. Demographic and clinical data were recorded at the time of the first QFT\u2010GIT test. Administration of preventive therapy and bDMARD treatments were recorded for patients with positive QFT\u2010GIT test. All new tuberculosis infections were recorded during the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final study population included 3028 patients (855 rheumatoid arthritis, 1001 psoriatic arthritis, 833 spondyloarthritis, 130 connective tissue diseases, 33 systemic vasculitis and 176 other inflammatory rheumatic conditions), more frequently female (67.2%), with a mean age of 52\u2009\u00b1\u200918\u2009years. Patients with QFT\u2010GIT\u2010positive test were elderly people, predominantly male with higher prevalence of diabetes as comorbidity. The 10\u2010year prevalence of LTBI was 10.8%. Of note, no cases of TB reactivation were recorded in patients who completed preventive therapy treatment. Three thousand and sixteen patients were followed over time (42.6\u00a0\u00b1\u200930\u2009months), and five (.2%) developed active TB, which corresponds to .47 cases per 1000 person\u2010years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the 10\u2010year observation, the use of bDMARDs seems to be safe in rheumatologic patients with positive QFT\u2010GIT test treated according to current recommendations. Nevertheless, cases of primary TB disease did occur during treatment with biologicals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13913","type":"journal-article","created":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T20:09:49Z","timestamp":1669579789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and management of tuberculosis infection in Apulian rheumatologic patients treated with biologics: An observational cohort 10\u2010year study from the <scp>BIOPURE<\/scp> registry"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1716-7432","authenticated-orcid":false,"given":"Marco","family":"Fornaro","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Emergence Medicine and Transplantation (DETO) University of Bari  Bari 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