{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:00:52Z","timestamp":1773252052658,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertension management in older patients represents a challenge, particularly when hospitalized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian in\u2010patients from internal medicine or geriatric wards) were considered; 4377 (77.2%) were hypertensive. Minimum treatment (MT) for hypertension was defined according to the 2018 ESC guidelines [an angiotensin\u2010converting\u2010enzyme\u2010inhibitor (ACE\u2010I) or an angiotensin\u2010receptor\u2010blocker (ARB) with a calcium\u2010channel\u2010blocker (CCB) and\/or a thiazide diuretic; if &gt;80\u2009years old, an ACE\u2010I or ARB or CCB or thiazide diuretic]. Determinants of MT discontinuation at discharge were assessed. Study outcomes were any cause rehospitalization\/all cause death, all\u2010cause death, cardiovascular (CV) hospitalization\/death, CV death, non\u2010CV death, evaluated according to the presence of MT at discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hypertensive patients were older than normotensives, with a more impaired functional status, higher burden of comorbidity and polypharmacy. A total of 2233 patients were on MT at admission, 1766 were on MT at discharge. Discontinuation of MT was associated with the presence of comorbidities (lower odds for diabetes, higher odds for chronic kidney disease and dementia). An adjusted multivariable logistic regression analysis showed that MT for hypertension at discharge was associated with lower risk of all\u2010cause death, all\u2010cause death\/hospitalization, CV death, CV death\/hospitalization and non\u2010CV death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Guidelines\u2010suggested MT for hypertension at discharge is associated with a lower risk of adverse clinical outcomes. Nevertheless, changes in antihypertensive treatment still occur in a significant proportion of older hospitalized patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13931","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T15:26:27Z","timestamp":1669908387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients"],"prefix":"10.1111","volume":"53","author":[{"given":"Sebastiano","family":"Cicco","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology (DIMO), Internal Medicine Unit \"Guido Baccelli\" and Unit of Arterial Hypertension \u201cAnna Maria Pirrelli\u201d University of Bari Aldo Moro, Azienda Ospedaliero\u2010Universitaria Policlinico  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"D\u2032Abbondanza","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, Perugia, Italy; Unit of Internal Medicine \u2018Santa Maria\u2019 Terni University Hospital  Terni Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1452-2478","authenticated-orcid":false,"given":"Marco","family":"Proietti","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health University of Milan  Milan Italy"},{"name":"Division of Subacute Care IRCCS Istituti Clinici Scientifici Maugeri  Milan Italy"},{"name":"Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart &amp; Chest Hospital  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Zaccone","sequence":"additional","affiliation":[{"name":"Internal and Subintensive Medicine Department Azienda Ospedaliero\u2010Universitaria \"Ospedali Riuniti\" di Ancona  Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Pes","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Internal Medicine Department University Hospital of Sassari  Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Caradio","sequence":"additional","affiliation":[{"name":"Emergency Department, Madonna del Soccorso Hospital  San Benedetto del Tronto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Azienda Ospedaliera 'Ospedali Riuniti Marche Nord'  Pesaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Piano","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine (DIMED) University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Maria","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, Interdisciplinary Research Centre in Biomedical Materials (C.R.I.B.) 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