{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:01:08Z","timestamp":1773457268781,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In aortic stenosis (AS), estimated glomerular filtration rate (eGFR) is an important prognostic marker but its haemodynamic determinants are unknown. We investigated the correlation between eGFR and invasive haemodynamics and long\u2010term mortality in AS patients undergoing aortic valve replacement (AVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 503 patients [median (interquartile range) age 76 (69\u201381) years] with AS [indexed aortic valve area .42 (.33\u2013.49) cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>] undergoing cardiac catheterization prior to surgical (72%) or transcatheter (28%) AVR. Serum creatinine was measured on the day before cardiac catheterization for eGFR calculation (CKD\u2010EPI formula).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median eGFR was 67 (53\u201382) mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>. There were statistically significant correlations between eGFR and mean right atrial pressure (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.13; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004), mean pulmonary artery pressure (mPAP; <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.25; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), mean pulmonary artery wedge pressure (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.19; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), pulmonary vascular resistance (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.21; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), stroke volume index (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.16; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), extent of coronary artery disease, and mean transvalvular gradient but not indexed aortic valve area. In multivariate linear regression, higher age, lower haemoglobin, lower mean transvalvular gradient (i.e. lower flow), lower diastolic blood pressure, and higher mPAP were independent predictors of lower eGFR. After a median post\u2010AVR follow\u2010up of 1348 (948\u20131885) days mortality was more than two\u2010fold higher in patients in the first eGFR quartile compared to those in the other three quartiles [hazard ratio 2.18 (95% confidence interval 1.21\u20133.94); <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with AS, low eGFR is a marker of an unfavourable haemodynamic constellation as well as important co\u2010morbidities. This may in part explain the association between low eGFR and increased post\u2010AVR mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13965","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T07:09:48Z","timestamp":1675667388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Estimated glomerular filtration rate, haemodynamics, and mortality in patients with aortic stenosis"],"prefix":"10.1111","volume":"53","author":[{"given":"Sharon","family":"Appert","sequence":"first","affiliation":[{"name":"Cardiology Department Kantonsspital St. Gallen  St. Gallen Switzerland"},{"name":"University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Weber","sequence":"additional","affiliation":[{"name":"Cardiology Department Kantonsspital St. Gallen  St. Gallen 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