{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:22:22Z","timestamp":1780568542191,"version":"3.54.1"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammation is closely related to cancer prognosis. The effect of celecoxib, a nonsteroidal anti\u2010inflammatory drug, on the prognosis of patients with cancer remains uncertain. To assess the association between celecoxib plus standard chemotherapy and cancer prognosis, we conducted a systematic review and meta\u2010analysis of published studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, and the Cochrane Library were searched from inception until July 2022 for randomized controlled trials reporting the prognosis of patients with cancer treated with celecoxib plus standard chemotherapy. The primary endpoints were overall survival (OS) and progression\u2010free survival (PFS). Meta\u2010analysis was performed using Review Manager software version 5.4. The following search terms were used in the databases: ((((celecoxib)) AND ((((((((cancer) OR (carcinoma)) OR (sarcoma)) OR (neoplasms)) OR (tumor)) OR (tumour)) OR (tumors)) OR (tumours))) AND ((survival) OR (mortality))) AND (((Clinical Trials, Randomized) OR (Trials, Randomized Clinical)) OR (Controlled Clinical Trials, Randomized)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 13 randomized controlled trials, including 8957 patients with cancer, were included in the analysis. Compared to conventional chemotherapy alone, 1\u2010year OS and 1\u2010year PFS rates were not significantly improved with celecoxib adjuvant therapy (OS: <jats:italic>p<\/jats:italic>\u00a0=\u00a0.38; PFS: <jats:italic>p<\/jats:italic>\u00a0=\u00a0.65). In addition, no differences were observed between the celecoxib and placebo groups in 3\u2010year overall (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.98), 3\u2010year progression\u2010free (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.40), 5\u2010year overall (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.59), or 5\u2010year progression\u2010free (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.56) survival rates. An increase in the risk ratio of leukopenia (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) and thrombocytopenia (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.05) was also observed, suggesting that celecoxib promotes hematologic toxicity. No increased risk of cardiovascular (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.96) and gastrointestinal (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.10\u2013.91) events was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The addition of celecoxib to standard chemotherapy did not improve OS or PFS rates of patients with cancer. Additionally, celecoxib can increase hematologic toxicity without increasing the risk of gastrointestinal or cardiovascular reactions. Further randomized controlled trials are necessary to clarify its effects and applications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.13973","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T18:53:23Z","timestamp":1676746403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of celecoxib plus standard chemotherapy on cancer prognosis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"53","author":[{"given":"Liangyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial &amp; Head and Neck Oncology Beijing Stomatological Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingrui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial &amp; Head and Neck Oncology Beijing Stomatological Hospital, 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