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Current pharmacotherapies show little therapeutic effect in AD treatment and still cannot prevent the pathological progression of AD. Deep brain stimulation (DBS) has shown to enhance memory in morbid obese, epilepsy and traumatic brain injury patients, and cognition in Parkinson's disease (PD) patients deteriorates during DBS off. Some relevant animal studies and clinical trials have been carried out to discuss the DBS treatment for AD. Reviewing the fornix trials, no unified conclusion has been reached about the clinical benefits of DBS in AD, and the dementia ratings scale has not been effectively improved in the long term. However, some patients have presented promising results, such as improved glucose metabolism, increased connectivity in cognition\u2010related brain regions and even elevated cognitive function rating scale scores. The fornix plays an important regulatory role in memory, attention, and emotion through its complex fibre projection to cognition\u2010related structures, making it a promising target for DBS for AD treatment. Moreover, the current stereotaxic technique and various evaluation methods have provided references for the operator to select accurate stimulation points. Related adverse events and relatively higher costs in DBS have been emphasized. In this article, we summarize and update the research progression on fornix DBS in AD and seek to provide a reliable reference for subsequent experimental studies on DBS treatment of AD.<\/jats:p>","DOI":"10.1111\/eci.13995","type":"journal-article","created":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T09:39:25Z","timestamp":1680428365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Deep brain stimulation of fornix in Alzheimer's disease: From basic research to clinical practice"],"prefix":"10.1111","volume":"53","author":[{"given":"Zhikun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji 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