{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:13:31Z","timestamp":1790313211906,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T00:00:00Z","timestamp":1680912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tobacco use is known to be involved in the development of cardiovascular diseases, which leads to premature mortality. Endothelial dysfunction, the first step in this process, was shown induced by smoking. It is reported that quitting smoking could reduce the risk of diseases, but the implied mechanisms are still unclear. This study aimed to evaluate the biological markers of endothelial function in smokers when actively smoking and after cessation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Quantification of several biomarkers reflecting inflammation, endothelium activation, oxidative stress, and lipids was performed in 65 smokers when actively smoking and after cessation (median abstinence duration of 70\u2009days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A possible decrease of inflammation was observed through the concentration reduction of a proinflammatory cytokine (interleukine\u20106) on quitting. A decrease of endothelium activation was visible by the reduced level of the soluble intercellular adhesion molecule. Two antioxidants, uric acid and vitamin C, were found at higher concentration than before the cessation, potentially reflecting the decrease of oxidative stress on quitting. Lipid profile was improved post\u2010quit since HDL level was increased and LDL level was decreased. All these effects were visible at short term with abstinence duration less than 70\u2009days. No sex\u2010specific difference was observed and no additional changes were observed for longer abstinence duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These observations suggest that some adverse effects of smoking on endothelial function could be reversible on quitting smoking. It could encourage smokers to enter a cessation program to reduce the risk for cardiovascular diseases development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.13996","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T10:09:34Z","timestamp":1680257374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Changes in biomarkers of endothelial function, oxidative stress, inflammation and lipids after smoking cessation: A cohort study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3559-5529","authenticated-orcid":false,"given":"Marie\u2010Lise","family":"Colsoul","sequence":"first","affiliation":[{"name":"Medical Laboratory CHU UCL Namur  1 avenue Dr Gaston Therasse 5530 Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2834-8967","authenticated-orcid":false,"given":"Nicolas","family":"Goderniaux","sequence":"additional","affiliation":[{"name":"Medical Laboratory CHU UCL Namur  1 avenue Dr Gaston Therasse 5530 Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7631-6051","authenticated-orcid":false,"given":"Sabrina","family":"Onorati","sequence":"additional","affiliation":[{"name":"Medical Laboratory CHU UCL Namur  1 avenue Dr Gaston Therasse 5530 Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5933-5275","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Medical Laboratory CHU UCL Namur  1 avenue Dr Gaston Therasse 5530 Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4051-9961","authenticated-orcid":false,"given":"Jacques","family":"Jamart","sequence":"additional","affiliation":[{"name":"Scientific Support Unit CHU UCL Namur  1 avenue Dr Gaston Therasse 5530 Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0649-8474","authenticated-orcid":false,"given":"Dominique","family":"Vanpee","sequence":"additional","affiliation":[{"name":"IRSS  30 Clos Chapelle\u2010aux\u2010champs 1200 Woluwe\u2010Saint\u2010Lambert Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-5616","authenticated-orcid":false,"given":"Ivan","family":"Berlin","sequence":"additional","affiliation":[{"name":"Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  47\u201083 boulevard de l'H\u00f4pital 75013 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-6566","authenticated-orcid":false,"given":"Laurence","family":"Galanti","sequence":"additional","affiliation":[{"name":"Medical Laboratory CHU UCL Namur  1 avenue Dr Gaston Therasse 5530 Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,8]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization Regional Office for Europe.European Tobacco Use: trends Report 2019.2019."},{"key":"e_1_2_11_3_1","unstructured":"World Health Organization (WHO).Tobacco.2022Accessed July 13 2022.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/tobacco"},{"key":"e_1_2_11_4_1","volume-title":"WHO Report on the Global Tobacco Epidemic, 2011: Warning about the Dangers of Tobacco","author":"World Health Organization","year":"2011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986707781058832"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2012.05.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0822-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.78319"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.047"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12755"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.29333\/ejeph\/12995"},{"key":"e_1_2_11_13_1","volume-title":"The Health Consequences of Smoking\u201450\u2009Years of Progress: A Report of the Surgeon General","author":"National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health","year":"2014"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.002"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115108"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.11.017"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.01067.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319719853458"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02449.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_11_21_1","unstructured":"European Medicines Agency (EMA).Good Clinical Practice.2018Accessed May 13 2022.https:\/\/www.ema.europa.eu\/en\/human\u2010regulatory\/research\u2010development\/compliance\/good\u2010clinical\u2010practice"},{"key":"e_1_2_11_22_1","volume-title":"Clinical Practice Guideline","author":"Agency for Health Care Policy and Research","year":"1996"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"issue":"12","key":"e_1_2_11_24_1","first-page":"1668","article-title":"Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy","volume":"11","author":"Jacob P","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntz132"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2022.123476"},{"key":"e_1_2_11_27_1","unstructured":"ColsoulML GoderniauxN OnoratiS et al.Anatabine and anabasine as specific biomarkers of smoking cessation: time to update the cutoff values?Manuscript Submitted for Publication2022."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.9.1460"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15051033"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2728"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02179.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2179"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510701283878"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.12.018"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.52"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/15257770802138558"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.09.023"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006219.pub3"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/2050-7771-1-26"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241993"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060937"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01643.x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa001"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.13996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T10:10:57Z","timestamp":1705659057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.13996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,8]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/eci.13996"],"URL":"https:\/\/doi.org\/10.1111\/eci.13996","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,8]]},"assertion":[{"value":"2023-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13996"}}