{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:47:24Z","timestamp":1784029644539,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070206"],"award-info":[{"award-number":["82070206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary liver cancer (PLC) is the sixth most frequently occurring cancer, representing one of the top 5 leading causes of cancer\u2010related mortality worldwide. Recently, researchers have focused more on the impact of living habits on the incidence and development of tumours. This study reports a relationship between sleep traits and PLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we used published genome\u2010wide association studies to obtain exposure factors of 6 sleep traits. Mendelian randomization (MR) analysis was used to assess the causal relationship between sleep traits and PLC via inverse\u2010variance weighted (IVW), MR Egger and weighted median. Sensitivity analysis was used to reduce the bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our investigation revealed that there was a negative correlation between sleep duration and the group of liver and bile duct cancer by IVW (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.042), and this result was similarly observed in the liver cell carcinoma group by Weighted Median (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.026). In contrast, there was a positive correlation found between napping during the day and primary liver cancer in the cohorts of liver and bile duct cancer (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.030), liver cell carcinoma (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.043) and malignant neoplasm of other and unspecified parts of the biliary tract (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.016) by IVW. Furthermore, our study also revealed a positive correlation between insomnia and malignant neoplasm of the liver and intrahepatic bile ducts by IVW (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, our study indicates that insomnia and nap during the day may be risk factors of PLC and adequate night sleep might keep us away from PLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14002","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T13:03:40Z","timestamp":1680959020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Association between sleep traits and primary liver cancer: A Mendelian randomization analysis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-9445","authenticated-orcid":false,"given":"Xin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Oncology Tianjin Union Medical Center, Nankai University  Tianjin China"},{"name":"The Institute of Translational Medicine Tianjin Union Medical Center of Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases Chu Hsien\u2010I Memorial Hospital &amp; Tianjin Institute of Endocrinology, Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Tianjin Union Medical Center, Nankai University  Tianjin China"},{"name":"The Institute of Translational Medicine Tianjin Union Medical Center of Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"issue":"22","key":"e_1_2_10_3_1","article-title":"Global burden of primary liver cancer in 2020 and predictions to 2040","volume":"0168","author":"Rumgay H","year":"2022","journal-title":"J Hepatol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.22.00118"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww124"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2005.07.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.918749"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-004-0032-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004109"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l2327"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.561"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25507"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy252"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-019-01156-4"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsab089"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-295"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2020.101729"},{"issue":"9","key":"e_1_2_10_19_1","first-page":"649","article-title":"Sleep duration and risk of lung cancer in the physicians' health study","volume":"17","author":"Khawaja O","year":"2014","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20446"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016010098"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr036"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0255-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7221"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002607"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09534"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6522"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-013-0811-x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101409"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2017.6412"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486577"},{"key":"e_1_2_10_37_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders. DSMIV","author":"American PA","year":"1994"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e3182037bf3"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2013.09.002"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29400"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0073-y"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2016.1167709"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0368-x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800419881195"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030518"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2015-1133"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-1030"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-15-331"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112780"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.727959"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.14002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T15:10:36Z","timestamp":1705677036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.14002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/eci.14002"],"URL":"https:\/\/doi.org\/10.1111\/eci.14002","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]},"assertion":[{"value":"2022-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14002"}}