{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T09:17:45Z","timestamp":1772097465255,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100273"],"award-info":[{"award-number":["82100273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012798"],"award-info":[{"award-number":["2023A1515012798"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transthyretin amyloid cardiomyopathy (ATTR\u2010CM) is often found in patients with heart failure with preserved ejection fraction (HFpEF). However, the evidence regarding ATTR\u2010CM and prognosis in HFpEF remains scarce. This study sought to determine whether the ATTR\u2010CM burden was associated with clinical outcomes in HFpEF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the associations of baseline ATTR\u2010CM score with adverse outcomes in HFpEF patients from the TOPCAT trial using the Cox proportional hazards model or the competing risk regression model. The discriminatory ability of the ATTR\u2010CM score was assessed using the area under the time\u2010dependent receiver operating characteristic curve (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 870 HFpEF patients, 18.9% of which had an ATTR\u2010CM score \u22656. Per 1 increment in the ATTR\u2010CM score was significantly associated with an increased risk of the primary outcome (adjusted hazard ratio [HR] 1.19, 95% confidence interval [CI] 1.12\u20131.27) with an AUC of 0.652 (0.594\u20130.711), whereas patients with ATTR\u2010CM score \u22656 presented higher risks of the primary outcome (adjusted HR 2.20, 95% CI 1.65\u20132.95). Similar results were observed toward the secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The simple ATTR\u2010CM score identified an 18.9% ATTR\u2010CM burden in HFpEF patients, and a higher ATTR\u2010CM burden might predict adverse outcomes with moderate discriminatory abilities in HFpEF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14045","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T09:01:21Z","timestamp":1687770081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A simple <scp>ATTR\u2010CM<\/scp> score to identify transthyretin amyloid cardiomyopathy burden in <scp>HFpEF<\/scp> patients"],"prefix":"10.1111","volume":"53","author":[{"given":"Min","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou People's Republic of 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