{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:40:42Z","timestamp":1790836842702,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are classified as different diseases but have many similar pathogenic genes and clinical symptoms. Previous research has focused on mutated genes. This study was conducted to identify key molecular mechanisms and explore effective therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Myocardial tissue was harvested from patients with HCM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093) or DCM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) during surgery. Hearts donated by healthy traffic accident victims were treated as controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094). Total proteins were extracted for liquid chromatography\u2013tandem mass spectrometry. Differentially expressed proteins (DEPs) were annotated via GO and KEGG analyses. Selected distinguishing protein abundance was confirmed by western blotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the control group, there were 121 and 76 DEPs in the HCM and DCM groups, respectively. GO terms for these two comparisons are associated with contraction\u2010related components and actin binding. Additionally, the most significantly upregulated and downregulated proteins were periostin and tropomyosin alpha\u20103 chain in both comparisons. Moreover, when comparing the HCM and DCM groups, we found 60 significant DEPs, and the GO and KEGG terms are related to the calcium signalling pathway. Expression of the calcium regulation\u2013related protein peptidyl\u2010prolyl cis\u2010trans isomerase (FKBP1A) was significantly upregulated in multiple samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HCM and DCM have many mutual pathogenetic pathways. Calcium ion\u2010related processes are among the most significant factors affecting disease development. For HCM and DCM, research on regulating linchpin protein expression or interfering with key calcium\u2010related pathways may be more beneficial than genetic research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.14051","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T01:12:22Z","timestamp":1688001142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiac proteomic profiling suggests that hypertrophic and dilated cardiomyopathy share a common pathogenetic pathway of the calcium signalling pathway"],"prefix":"10.1111","volume":"53","author":[{"given":"Wenjuan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery The Second Affiliated Hospital of Army Medical University  Chongqing 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