{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:25:41Z","timestamp":1777559141277,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Circulating endotoxins could result from bacterial digestive translocation during sepsis, thus contributing to uncontrolled systemic inflammation, leading in turn to organ dysfunction. We addressed this issue in the setting of severe pneumococcal pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Endotoxemia was measured in a clinically relevant rabbit model of ventilated pneumococcal pneumonia and in 110 patients with bacteraemic pneumonia, using a patented mass spectrometry (LC\u2013MS\/MS) method for detection of 3\u2010OH fatty acids (C10, C12, C14, C16 and C18), which are molecules bound to the lipid A motif of LPS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Whereas higher levels of systemic inflammation and organ dysfunctions were found, there was no significant difference in lipopolysaccharide concentrations when infected rabbits were compared to non\u2010infected ones, or when patients were compared to healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Seemingly, endotoxins do not drive the overwhelming inflammation associated with severe forms of pneumococcal pneumonia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14077","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T11:15:12Z","timestamp":1693307712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pneumococcal pneumonia and endotoxemia: An experimental and clinical reappraisal"],"prefix":"10.1111","volume":"54","author":[{"given":"Jeanne","family":"Godon","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Dijon\u2010Bourgogne University Hospital  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Emmanuel","family":"Charles","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Dijon\u2010Bourgogne University Hospital  Dijon France"},{"name":"Lipness Team, INSERM Research Centre LNC\u2010UMR1231 and LabEx LipSTIC University of Burgundy  Dijon 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