{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:52:51Z","timestamp":1776286371996,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adverse left ventricular (LV) remodelling after myocardial infarction is associated with heart failure. We investigated whether aortic stiffness during acute ST\u2010segment elevation myocardial infarction is associated with LV remodelling at long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 109 patients within 48\u2009h of myocardial infarction post\u2010primary percutaneous coronary intervention and after 2\u2009years, we measured: (a) carotid to femoral pulse wave velocity (PWV), (b) LV global longitudinal strain (GLS) and left atrial strain using speckle\u2010tracking echocardiography, (c) PWV\/GLS ratio as a surrogate marker of ventricular\u2010arterial interaction, and (d) LV end\u2010diastolic and end\u2010systolic volumes. A\u2009&gt;\u200915% decrease from the baseline in LV end\u2010systolic volume at 2\u2010year follow\u2010up was considered as a criterion of reverse LV remodelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with baseline, all patients had reduced PWV, LV end\u2010diastolic and end\u2010systolic volumes while PWV\/GLS, GLS and reservoir left atrial strain were improved (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) after 2\u2009years. Baseline values of PWV, GLS, PWV\/GLS ratio and reservoir left atrial strain were associated with percentage change of LV end\u2010systolic volume at 2\u2009years (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Multivariable analysis revealed that lower baseline values of PWV and a less impaired GLS and PWV\/GLS were independently associated with reverse LV remodelling at 2\u2009years with a C\u2010statistic of .748, .711 and .787, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aortic stiffness early post\u2010infarction determines LV remodelling after 2\u2009years of the ischemic event despite post successful revascularization.<\/jats:p><jats:p>Clinical Trial Registration\u2010URL: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>. Unique identifier: NCT03984123, 30\/04\/2020.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14090","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:18:52Z","timestamp":1694078332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of aortic stiffness early post myocardial infarction with left ventricular remodelling"],"prefix":"10.1111","volume":"54","author":[{"given":"George","family":"Pavlidis","sequence":"first","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital, Medical School, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damianos","family":"Tsilivarakis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital, Medical School, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1631-5210","authenticated-orcid":false,"given":"Konstantinos","family":"Katogiannis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital, Medical School, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Vlastos","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital, Medical School, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyridon","family":"Katsanos","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital, Medical School, National and Kapodistrian University of Athens  Athens 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