{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:28:30Z","timestamp":1753878510997,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202201011014"],"award-info":[{"award-number":["202201011014"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100387","82200415","82270399"],"award-info":[{"award-number":["82100387","82200415","82270399"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018540","name":"Science Fund for Distinguished Young Scholars of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010227","2022A1515010785","2022A1515012161"],"award-info":[{"award-number":["2022A1515010227","2022A1515010785","2022A1515012161"]}],"id":[{"id":"10.13039\/501100018540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010114"],"award-info":[{"award-number":["2021A1515010114"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sodium abnormality is common in patients with heart failure (HF) and is associated with adverse clinical outcomes. The aim of this study is to determine the impact of abnormal sodium burden on long\u2010term mortality and hospitalization in HF with preserved ejection fraction (HFpEF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed participants from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial with available baseline and follow\u2010up data (<jats:italic>n<\/jats:italic>\u2009=\u20091717). Abnormal sodium burden was defined as the proportion of days with abnormal sodium plasma levels (either &lt;135\u2009mmol\/L or\u2009&gt;\u2009145\u2009mmol\/L). To determine the independent prognostic impact of abnormal sodium burden on the long\u2010term clinical adverse outcomes (The primary outcome was any cause death, the secondary outcomes include cardiovascular disease death, HF hospitalization, any cause hospitalization and the primary endpoint of the original study), a multivariable Cox proportional hazard model and time\u2010updated Cox regression model were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abnormal sodium burden occurred in 717 patients (41.76%). A high abnormal sodium burden was associated with 1.47 (95% CI, 1.15\u20131.89) higher risk with any cause mortality, 1.51 (95% CI, 1.08\u20132.09) higher risk with CVD death and 1.31 (95% CI, 1.02\u20131.69) higher risk with HF hospitalization when compared with no burden group. When sodium level changes over time were accounted for in time\u2010updated models, abnormal sodium level was still associated with poor clinical outcomes. Diuretic and spironolactone usage did not show a statistical interaction effect on the prognostic significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In HFpEF patients, abnormal sodium burden was an independent predictor long\u2010term any\u2010cause mortality and HF hospitalization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14115","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T12:04:41Z","timestamp":1698235481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of abnormal sodium burden in heart failure patients with preserved ejection fraction"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4125-3322","authenticated-orcid":false,"given":"Zhe","family":"Zhen","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou PR China"},{"name":"NHC Key Laboratory of Assisted Circulation and Vascular Diseases Sun Yat\u2010sen University  Guangzhou PR China"},{"name":"National\u2010Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases  Guangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manting","family":"Choy","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou PR China"},{"name":"NHC Key Laboratory of Assisted Circulation and Vascular Diseases Sun Yat\u2010sen University  Guangzhou PR China"},{"name":"National\u2010Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases  Guangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou PR China"},{"name":"NHC Key Laboratory of Assisted Circulation and Vascular Diseases Sun Yat\u2010sen University  Guangzhou PR China"},{"name":"National\u2010Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases  Guangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou PR China"},{"name":"NHC Key Laboratory of Assisted Circulation and Vascular Diseases Sun Yat\u2010sen University  Guangzhou PR China"},{"name":"National\u2010Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases  Guangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-9184","authenticated-orcid":false,"given":"Weihao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou PR China"},{"name":"NHC Key Laboratory of Assisted Circulation and Vascular Diseases Sun Yat\u2010sen University  Guangzhou PR China"},{"name":"National\u2010Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases  Guangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9818-0454","authenticated-orcid":false,"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou PR China"},{"name":"NHC Key Laboratory of Assisted Circulation and Vascular Diseases Sun Yat\u2010sen University  Guangzhou PR China"},{"name":"National\u2010Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases  Guangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9595-7785","authenticated-orcid":false,"given":"Ruicong","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou PR China"},{"name":"NHC Key Laboratory of Assisted Circulation and Vascular Diseases Sun Yat\u2010sen University  Guangzhou PR China"},{"name":"National\u2010Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases  Guangzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-015-9482-y"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9193-3"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.03.002"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7133.2010.00206.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440150068007"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073931"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.2.257"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp032"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.021733"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014140"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.03.040"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14836"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313731"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.03.001"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14388"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.830042"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000165065.82609.3D"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.065391"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.18.1998"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr086"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20560"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0878"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-008-9109-7"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.17-024"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.14115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T09:57:20Z","timestamp":1706003840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.14115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,25]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/eci.14115"],"URL":"https:\/\/doi.org\/10.1111\/eci.14115","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"type":"print","value":"0014-2972"},{"type":"electronic","value":"1365-2362"}],"subject":[],"published":{"date-parts":[[2023,10,25]]},"assertion":[{"value":"2023-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14115"}}