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Zinc finger proteins (ZNPs) are key regulators of transcription and have emerged as potential contributors to cancer drug resistance. Bridging the knowledge gap between ZNPs and MDR is essential to understand a source of heterogeneity in cancer treatment. This review sought to elucidate how different ZNPs modulate the transcriptional regulation of ABC genes, contributing to resistance to cancer therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The search was conducted using PubMed, Google Scholar, EMBASE and Web of Science.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In addition to ABC\u2010blockers, the transcriptional features regulated by ZNP are expected to play a role in reversing ABC\u2010mediated MDR and predicting the efficacy of anticancer treatments. Among the ZNP\u2010induced epithelial to mesenchymal transition, SNAIL, SLUG and Zebs have been identified as important factors in promoting MDR through activation of ATM, NF\u03baB and PI3K\/Akt pathways, exposing the metabolism to potential ZNP\u2010MDR interactions. Additionally, nuclear receptors, such as VDR, ER and PXR have been found to modulate certain ABC regulations. Other C2H2\u2010type zinc fingers, including Kruppel\u2010like factors, Gli and Sp also have the potential to contribute to MDR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Besides reviewing evidence on the effects of ZNP dysregulation on ABC\u2010related chemoresistance in malignancies, significant markers of ZNP functions are discussed to highlight the clinical implications of gene\u2010to\u2010gene and microenvironment\u2010to\u2010gene interactions on MDR prospects. Future research on ZNP\u2010derived biomarkers is crucial for addressing heterogeneity in cancer therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14120","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T12:58:51Z","timestamp":1699275531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Zinc finger proteins and <scp>ATP<\/scp>\u2010binding cassette transporter\u2010dependent multidrug resistance"],"prefix":"10.1111","volume":"54","author":[{"given":"Sanaz","family":"Barzegar","sequence":"first","affiliation":[{"name":"Shahid Madani Hospital Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Molecular Medicine Research Center Tabriz University of Medical Sciences  Tabriz 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