{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T21:52:25Z","timestamp":1774561945972,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a lack of noninvasive diagnostic methods for nonalcoholic steatohepatitis (NASH), the severe condition of metabolic dysfunction\u2010associated steatotic liver disease (MASLD). Platelet activation, evaluated through certain related parameters, is associated with liver disease and inflammation, but previous results are inconclusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the potential utility of platelet\u2010related indices as noninvasive diagnostic markers for the detection and prediction of MASLD, focusing on NASH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW) were increased in the severe and morbidly obese (SMO) group compared to the normal weight (NW) group. We found decreased levels of MPV in steatosis and NASH patients. MPV and PCT values were decreased in the presence of mild liver inflammation. Platelet count (PLA) and PCT values were lower in the presence of ballooning. We obtained an area under the ROC curve of 0.84 using MPV and three other variables to predict MASLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Some platelet\u2010related indices vary depending on liver condition. Here, we reported decreased MPV in MASLD presence. Moreover, we presented for the first time a predictive model using MPV, ALT levels and the presence of diabetes mellitus and metabolic syndrome to predict MASLD in obese women. Also, MPV is closely related to early liver inflammation in NASH, and PLA and PCT are related to hepatic ballooning. These indices could be widely used for the early detection of NASH since they are usually determined in routine laboratory tests.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14123","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T12:30:25Z","timestamp":1699273825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Platelet\u2010associated biomarkers in nonalcoholic steatohepatitis: Insights from a female cohort with obesity"],"prefix":"10.1111","volume":"54","author":[{"given":"Joan","family":"Duran\u2010Bertran","sequence":"first","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"},{"name":"Servei Medicina Interna, Departament de Medicina i Cirurgia Hospital Universitari de Tarragona Joan XXIII, URV  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Cristina","family":"Rusu","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Barrientos\u2010Riosalido","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Bertran","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razieh","family":"Mahmoudian","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Riesco","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"},{"name":"Servei Medicina Interna, Departament de Medicina i Cirurgia Hospital Universitari de Tarragona Joan XXIII, URV  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salom\u00e9","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"},{"name":"Servei Anatomia Patol\u00f2gica Hospital Universitari de Tarragona Joan XXIII  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Ugarte\u00a0Chicote","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"},{"name":"Servei Anatomia Patol\u00f2gica Hospital Universitari de Tarragona Joan XXIII  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e0tima","family":"Sabench","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"},{"name":"Servei de Cirurgia, Departament de Medicina i Cirurgia Hospital Sant Joan de Reus, URV, IISPV  Reus Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crist\u00f3bal","family":"Richart","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0396-6428","authenticated-orcid":false,"given":"Teresa","family":"Auguet","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR) \u2013 Medicina Aplicada (URV), Departament de Medicina i Cirurgia Universitat Rovira i Virgili (URV), Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tarragona Spain"},{"name":"Servei Medicina Interna, Departament de Medicina i Cirurgia Hospital Universitari de Tarragona Joan XXIII, URV  Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00523-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323202"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190117102111"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.02.012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.10.003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11926-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00407.2012"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.920172"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537100903391023"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21496"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01174-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100701230444"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8867985"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-018-0865-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/834153"},{"key":"e_1_2_11_19_1","first-page":"1300","article-title":"How obesity affects the neutrophil\/lymphocyte and platelet\/lymphocyte ratio, systemic immune\u2010inflammatory index and platelet indices: a retrospective study","volume":"20","author":"Furuncuo\u011flu Y","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_11_20_1","first-page":"22557","article-title":"The evaluation of carotid intima\u2010media thickness and mean platelet volume values and correlation with cardiac functions in obese children","volume":"8","author":"\u00d6zkan EA","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.07.015"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063113"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1604091"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2012.688898"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2010.540049"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-022-01330-8"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24721"},{"key":"e_1_2_11_28_1","first-page":"175","article-title":"Comparison of haematological parameters in patients with non\u2010alcoholic fatty liver disease and alcoholic liver disease","volume":"52","author":"Das SK","year":"2011","journal-title":"Singapore Med J"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2014-0303"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00317-X"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31101"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0379-5"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060516650076"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835d08da"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000401"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320622"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000486"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9213074"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2797"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1724"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2008.01.006"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-20-0209"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2011.589014"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688542"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32751-1"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.25884"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P037614"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.18231\/2581-3706.2018.0061"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190180"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.06.021"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0812-z"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.14123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T09:49:39Z","timestamp":1707817779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.14123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,6]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/eci.14123"],"URL":"https:\/\/doi.org\/10.1111\/eci.14123","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,6]]},"assertion":[{"value":"2023-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14123"}}