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SGLT\u20102 inhibitors have potential anti\u2010proliferative roles due to several underlying pathophysiological mechanisms, such as inhibition of ATP production, activation of AMPK signalling, induction of apoptosis and ferroptosis, inhibition of glutamate dehydrogenase activity and inhibition of DNA and RNA synthesis. However, heterogeneity among tumour cells and SGLT\u20102 inhibitor drugs limit the generalizability of pre\u2010clinical studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a narrative review discussing the potential anti\u2010cancer effects of SGLT\u20102 inhibitors, an oral glucose\u2010lowering medication used in patients with type II diabetes mellitus. This review discusses underlying mechanisms, pre\u2010clinical and clinical trial data, epidemiological data and future perspectives on the use of SGLT\u20102 inhibitors in cancer treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Type II diabetes is linked to various comorbidities and malignancies, but some glucose\u2010slowering medications may have a preventive role in cancer. The use of SGLT\u20102 inhibitors was associated with bladder cancer based on mice studies. However, meta\u2010analyses showed no significant increase in overall malignancy incidence of any specific type, except for empagliflozin and bladder cancer association. SGLT\u20102 inhibitors can potentially reduce the heart damage caused by doxorubicin and sunitinib, while enhancing the anti\u2010cancer effects of doxorubicin. Combining SGLT\u20102 inhibitors with doxorubicin may allow higher doses of chemotherapy use. Multiple ongoing clinical trials are investigating the potential therapeutic potential of SGLT\u20102 inhibitors in various types of cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More large\u2010scale pre\u2010clinical and clinical studies are needed to explore their potential preventive and therapeutic roles of SGLT\u20102 inhibitors in cancer treatment. In this narrative review, our aim is to explore the pre\u2010clinical and clinical data regarding the potential anti\u2010cancer effects of SGLT\u20102 inhibitors including the hypothetical pathophysiological mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14131","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:38:34Z","timestamp":1701131914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Is there any robust evidence showing that <scp>SGLT2<\/scp> inhibitor predisposes to cancer?"],"prefix":"10.1111","volume":"54","author":[{"given":"Sidar","family":"Copur","sequence":"first","affiliation":[{"name":"Department of Medicine Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8921-2736","authenticated-orcid":false,"given":"Abdullah B.","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Medicine Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Covic","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine Grigore T. 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