{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:40:51Z","timestamp":1775040051392,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007479","name":"Fondazione Cassa di Risparmio di Padova e Rovigo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>An acute depletion of circulating haematopoietic stem\/progenitor cells (HSPCs) occurs during COVID\u201019, especially among patients with a poorer disease course. We herein examined whether HSPCs levels at hospital admission for COVID\u201019 predict 1\u2010year mortality and the long\u2010COVID syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients hospitalized for COVID\u201019 in an infectious disease ward were consecutively enrolled. Circulating HSPC levels were assessed by flow cytometry as cells expressing CD34 and\/or CD133. Follow\u2010up was performed for 12\u2009months after hospitalization through the review of electronic medical records and demographic local registers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 100 patients, 36 of whom reported symptoms of long\u2010COVID and 20 died during follow\u2010up. The reduction of 1\u2010SD of HSPCs was associated with a 3\u2010 to 5\u2010fold increase in the risk of 1\u2010year mortality. Age, admission hyperglycaemia, C\u2010reactive protein peak, liver enzymes, the need of high\u2010flow oxygen and\/or invasive ventilation were predictors of mortality at univariate analysis. Among pre\u2010existing comorbidities, coronary heart disease and chronic kidney disease, but not diabetes, were associated with 1\u2010year mortality. In multivariate analyses, HSPCs remained significantly associated with 1\u2010year mortality independently of confounders. The development of pneumonia an in\u2010hospital treatment with glucocorticoids and convalescent plasma were associated with long\u2010COVID symptoms at follow\u2010up. HSPCs, diabetes and other comorbidities were not predictors of long\u2010COVID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a cohort of patients hospitalized for COVID\u201019, lower HSPC levels at the time of admission were independent predictors of 1\u2010year mortality. However, COVID\u201019 severity, but not HSPC level, was significantly associated with the development of long\u2010COVID symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14150","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T10:54:32Z","timestamp":1702464872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Circulating haematopoietic stem cells and long\u2010term outcomes of <scp>COVID<\/scp>\u201019"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-2723","authenticated-orcid":false,"given":"Benedetta Maria","family":"Bonora","sequence":"first","affiliation":[{"name":"Department of Medicine University Hospital of Padova  Padua Italy"},{"name":"Veneto Institute of Molecular Medicine  Padua 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