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Cerebral embolism protection (CEP) devices can divert or trap debris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the efficacy of CEP during TAVI vs the standard procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>PubMed, SCOPUS and DOAJ 1\/01\/2014\u201304\/12\/2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Selection<\/jats:title><jats:p>Randomized and observational studies comparing CEP versus standard TAVI, according to PRISMA. Primary outcome: stroke. Secondary outcomes: death, bleeding, vascular access complications, acute kidney injury and infarct area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Extraction<\/jats:title><jats:p>Two investigators independently assessed study quality and extracted data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Synthesis<\/jats:title><jats:p>Twenty\u2010six articles were included (<jats:italic>540.247<\/jats:italic> patients). The primary endpoint was significantly lower (RR\u2009=\u20090.800 95%CI:0.682\u20130.940; <jats:italic>p<\/jats:italic>\u2009=\u20090.007) with CEP. Similarly, death rates were significantly lower with CEP (RR\u2009=\u20090.610 95%CI:0.482\u20130.771; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No difference was found for bleeding (RR\u2009=\u20091.053 95%CI:0.793\u20131.398; <jats:italic>p<\/jats:italic>\u2009=\u20090.721), vascular complications (RR\u2009=\u20090.937 95%CI:0.820\u20131.070; <jats:italic>p<\/jats:italic>\u2009=\u20090.334) or AKI (RR\u2009=\u20090.982 95%CI:0.754\u20131.279; <jats:italic>p<\/jats:italic>\u2009=\u20090.891).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of CEP during TAVI is associated with improved outcomes. Future studies will identify patients who benefit most from CEP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14166","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T09:48:33Z","timestamp":1706176113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical impact of cerebral protection during transcatheter aortic valve implantation"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8997-2356","authenticated-orcid":false,"given":"Fabiola","family":"Boccuto","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences \"Magna Graecia\" University  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Carabetta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences \"Magna Graecia\" University  Catanzaro 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