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Little is known on epigenetic determinants in CS. Here, we investigated plasma miRNAs in relation to CS stratification in STEMI\u2010patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>STEMI\u2010patients (<jats:italic>n<\/jats:italic>\u2009=\u200949), with (CS, <jats:italic>n<\/jats:italic>\u2009=\u200925) and without CS (non\u2010CS, <jats:italic>n<\/jats:italic>\u2009=\u200924) fulfilling inclusion criteria were included from HSCSP\u2010cohort (Derivation\u2010cohort). CS\u2010miRNAs were analysed by Affymetrix\u2010microarray and RT\u2010PCR. Results were validated in a second cohort of CS\u2010patients (CardShock: <jats:italic>n<\/jats:italic>\u2009=\u200935) with similar inclusion\/exclusion criteria as the derivation cohort. In silico analysis were performed to identify potential miRNA target genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 5\u2010miRNA signature obtained from microarray analysis, miR\u2010619\u20105p showed higher levels in CS than in Non\u2010CS patients (<jats:italic>p<\/jats:italic>\u2009=\u2009.003) and discriminating power for CS by ROC (AUC: .752, <jats:italic>p<\/jats:italic>\u2009=\u2009.003). miR\u2010619\u20105p directly associated with risk scores [GRACE, <jats:italic>p<\/jats:italic>\u2009=\u2009.001; CardShock, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001]. Furthermore, miR\u2010619\u20105p showed discrimination power for death in CS. Thus, miRNA levels were significantly higher in patients with mortality outcome both in the Derivation HSCSP\u2010cohort (<jats:italic>p<\/jats:italic>\u2009=\u2009.02; AUC: .78\u2009\u00b1\u2009.095) and the Validation CardShock\u2010cohort (<jats:italic>p<\/jats:italic>\u2009=\u2009.017; AUC: .737\u2009\u00b1\u2009.086) By in silico analysis, miR\u2010619\u20105p target genes and TNF\u2010alpha were involved in the regulation of inflammation. miR\u2010619\u20105p and TNF\u2010alpha levels discriminated mortality outcome in CS\u2010patients during 30\u2010day follow\u2010up (Validation\u2010Cohort: ROC: .812, <jats:italic>p<\/jats:italic>\u2009=\u2009.002; HR: 9.99, <jats:italic>p<\/jats:italic>\u2009=\u2009.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Up\u2010regulation of miR\u2010619\u20105p is found in the plasma of STEMI\u2010patients with CS and mortality outcome. These findings highlight the specificity of epigenetic regulation of inflammation on the disease severity of MI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14186","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T12:57:53Z","timestamp":1708433873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>miR<\/scp>\u2010619\u20105p and cardiogenic shock in patients with <scp>ST\u2010segment elevation<\/scp> myocardial infarction"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-7244","authenticated-orcid":false,"given":"Rafael","family":"Escate","sequence":"first","affiliation":[{"name":"Cardiovascular\u2010Program ICCC Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Cardiovascular (CIBERCV), Instituto de Salud Carlos III  Madrid 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