{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:42:54Z","timestamp":1788237774694,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the last few years, percutaneous LAA occlusion (LAAO) has become a plausible alternative in atrial fibrillation (AF) patients with contraindications to anticoagulation therapy. Nevertheless, the optimal antiplatelet strategy following percutaneous LAAO remains to be defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Studies comparing single antiplatelet therapy (SAPT) versus dual antiplatelet therapy (DAPT) following LAAO were systematically searched and screened. The outcomes of interest were ischemic stroke, device\u2010related thrombus (DRT) and major bleeding. A random\u2010effect meta\u2010analysis was performed comparing outcomes in both groups. The moderator effect of baseline characteristics on outcomes was evaluated by univariate meta\u2010regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen observational studies with 3255 patients treated with antiplatelet therapy (SAPT, <jats:italic>n<\/jats:italic>\u2009=\u20091033; DAPT, <jats:italic>n<\/jats:italic>\u2009=\u20092222) after LAAO were included. Mean age was 74.5\u2009\u00b1\u20098.3\u2009years, mean CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc and HAS\u2010BLED scores were 4.3\u2009\u00b1\u20091.5 and 3.2\u2009\u00b1\u20091.0, respectively. At a weighted mean follow\u2010up of 12.7\u2009months, the occurrence of stroke (RR 1.33; 95% CI 0.64\u20132.77; <jats:italic>p<\/jats:italic>\u2009=.44), DRT (RR 1.52; 95% CI 0.90\u20132.58; <jats:italic>p<\/jats:italic>\u2009=.12), and the composite of stroke and DRT (RR 1.26; 95% CI 0.67\u20132.37; <jats:italic>p<\/jats:italic>\u2009=.47) did not differ significantly between SAPT and DAPT groups. The rate of major bleedings was also not different between groups (RR 1.41; 95% CI 0.64\u20133.12; <jats:italic>p<\/jats:italic>\u2009=.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among AF patients at high bleeding risk undergoing percutaneous LAAO, a post\u2010procedural minimalistic antiplatelet strategy with SAPT did not significantly differ from DAPT regimens regarding the rate of stroke, DRT and major bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14209","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T10:48:26Z","timestamp":1712746106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Single versus dual antiplatelet therapy following percutaneous left atrial appendage closure\u2014A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"54","author":[{"given":"Saverio","family":"Continisio","sequence":"first","affiliation":[{"name":"Division of Cardiology, Clinica S. 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