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Obesity and diabetes are the most important risk factors of MASLD. It is well\u2010established that obesity\u2010associated insulin resistance leads to a situation of tissue lipotoxicity characterized by an accumulation of excess fat in non\u2010fat tissues such as the liver, promoting the development of MASLD, and its progression into metabolic dysfunction\u2010associated steatohepatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we aimed to review the impact of disrupted intestinal permeability, antimicrobial proteins and bacterial endotoxin in the development and progression of MASLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion<\/jats:title>\n                    <jats:p>Recent studies demonstrated that obesity\u2010 and obesogenic diets\u2010associated alterations of intestinal microbiota along with the disruption of intestinal barrier integrity, the alteration in antimicrobial proteins and, in consequence, an enhanced translocation of bacterial endotoxin into bloodstream might contribute to this pathological process through to impacting liver metabolism and inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.14224","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T09:15:08Z","timestamp":1713431708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The relevance of intestinal barrier dysfunction, antimicrobial proteins and bacterial endotoxin in metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1111","volume":"54","author":[{"given":"Ina","family":"Bergheim","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, Molecular Nutritional Science University of Vienna  Vienna 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