{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:47:04Z","timestamp":1791776824141,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the involvement of LINC02605 in the progression of paediatric <jats:italic>Mycoplasma pneumoniae<\/jats:italic> pneumonia (MPP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and thirty\u2010two children with MPP (90 simple MPP and 42 MPP\u2009+\u2009diarrhoea) were enrolled, and their plasma was collected for detection of LINC026505 expression. CCK\u20108 kit and commercial apoptosis kit were introduced to determine cell growth and apoptosis. In silico prediction analyses were conducted to predict the downstream miRNA for LINC02605, following verification by dual luciferase reporter assay. The lipid\u2010associated membrane proteins (LAMPs) were used to treat A549 and Coca\u20102 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LIN02605 was highly expressed in the MPP, especially in MPP complicated with diarrhoea. LINC02605 downregulation in A549 cells correlated with significant suppression of cell apoptosis rate and growth inhibition rate in\u00a0vitro. Introduction of miR\u2010539\u20105p inhibited luciferase activity in a reporter system containing the wild\u2010type LINC02605 and CXCL1. After stimulation with LAMPs, overexpression of LINC02605 and CXCL1 and inhibition of miR\u2010539\u20105p were found. miR\u2010539\u20105p and CXCL1 knockdown resulted in a rescue effect on the LINC02605\u2010inhibited cell apoptosis. LAMPs induced IL\u20101\u03b2 in intestinal epithelial cells and IL\u20101\u03b2 induced LINC02605 expression in A549 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LINC02605 was upregulated in MPP and miR\u2010539\u20105p was a target for LINC02605. LINC02605 may be involved in the crosstalk between the gastrointestinal tract and the respiratory tract.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14234","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:35:00Z","timestamp":1714062900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>LINC02605<\/scp> involved in paediatric <i>Mycoplasma pneumoniae<\/i> pneumonia complicated with diarrhoea via <scp>miR<\/scp>\u2010539\u20105p\/<scp>CXCL1<\/scp> axis"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0556-9128","authenticated-orcid":false,"given":"Yang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Yancheng City Dafeng People's Hospital  Yancheng Jiangsu 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