{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:30Z","timestamp":1787014110476,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter aortic valve implantation (TAVI) is increasingly being used in younger patients and those with lower peri\u2010procedural risk, meaning more patients will live long enough to experience structural valve deterioration (SVD) of the bioprosthesis, indicating repeated TAVI. Experience of repeated TAVI\u2014transcatheter heart valve (THV) implantation into an index THV is limited. This registry aims to assess the peri\u2010procedural and short\u2010term safety, efficacy and durability of repeated TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ReTAVI Prospective observational registry is an investigator\u2010initiated, multicentre, international, prospective registry of patients undergoing repeated TAVI using balloon\u2010expandable SAPIEN prosthesis to evaluate procedural and short\u2010term safety, efficacy and durability as well as anatomical and procedural factors associated with optimal results. The registry will enrol at least 150 patients across 60 high\u2010volume centres. Patients must be \u226518\u2009years old, have had procedural success with their first TAVI, have index THV device failure, intend to undergo repeated TAVI and be considered suitable candidates by their local Heart Team. All patients will undergo a 30\u2010day and 12\u2010month follow\u2010up. The estimated study completion is 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The registry will collect pre\u2010, peri\u2010, postoperative and 12\u2010months data on patients undergoing repeated TAVI procedures with THVs for failure of the index THV and determine VARC\u20103\u2010defined efficacy and safety at 30\u2009days and functional outcome at 12\u2009months. The registry will expand existing data sets and identify patient characteristics\/indicators related to complications and clinical benefits for patients with symptomatic severe calcific degenerative aortic stenosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.14241","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T07:24:07Z","timestamp":1716189847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Procedural and clinical outcomes of patients undergoing a TAVI in TAVI procedure: Rationale and design of the multicentre, prospective, observational ReTAVI registry"],"prefix":"10.1111","volume":"54","author":[{"given":"Radoslaw","family":"Parma","sequence":"first","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joner","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance  Munich Germany"},{"name":"Department of Cardiology, Deutsches Herzzentrum M\u00fcnchen Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Saia","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Cardio\u2010Thoraco\u2010Vascular Department Policlinico S. Orsola\u2010Malpighia, University Hospital of Bologn  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cuisset","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie Centre Hospitalier Universitaire de Timone  Marseille France"},{"name":"Aix Marseille Universit\u00e9, INSERM, INRA, C2VN &amp; Facult\u00e9 de M\u00e9decine  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Germans Trias i Pujol  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rodes\u2010Cabau","sequence":"additional","affiliation":[{"name":"Department of Cardiology Quebec Heart and Lung Institute, Laval University  Qu\u00e9bec 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