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Increased blood PTX\u20103 concentrations have been observed in a wide range of conditions, from infectious to cardiovascular disorders. Since its increase is more rapid than C\u2010reactive protein (CRP), PTX\u20103 can be useful to detect and monitor early inflammation. To dissect its pathophysiological role in rheumatic diseases (RD), we conducted a systematic review and meta\u2010analysis comparing blood PTX\u20103 concentrations in RD patients and healthy individuals and investigating possible associations with clinical, demographic, and study characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a search of published evidence until April 2024 in PubMed, Web of Science and Scopus, which led to the selection of 60 relevant manuscripts from a total of 1072 records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our synthesis revealed a statistically significant difference in PTX\u20103 concentrations between RD patients and controls (standard mean difference, SMD\u2009=\u20091.02, 95% CI 0.77\u20131.26, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), that correlated with CRP concentrations. The effect size was associated with geographical region of study conduction, RD type, with a reduction of the observed heterogeneity in patients with low LDL\u2010cholesterol and triglycerides concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study has shown a significant increase in blood PTX\u20103 concentrations in RD patients, which was associated with specific patient characteristics. Nevertheless, additional studies are needed to better define the utility of measuring PTX\u20103 in the early phase of RD. Our study was conducted in compliance with the PRISMA 2020 statement (study protocol available at PROSPERO CRD42024516600).<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14257","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T08:15:59Z","timestamp":1716970559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between blood Pentraxin\u20103 concentrations and rheumatic diseases: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6030-2583","authenticated-orcid":false,"given":"Biagio","family":"Di\u00a0Lorenzo","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari  Sassari 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