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Afterload\u2010independent left ventricular stroke work index (LVSWI) is alternatively recommended by the current guideline; however, pulmonary artery catheters are rarely inserted in organ donors in most jurisdictions. We propose a novel non\u2010invasive echocardiographic parameter, Pressure\u2010Strain Product (PSP), as a potential surrogate of catheter\u2010based LVSWI. This study aimed to investigate if PSP could correlate with catheter\u2010based LVSWI in an ovine model of brain stem death (BSD) donors. The association between PSP and myocardial mitochondrial function in the post\u2010transplant hearts was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one female sheep (weight 47\u2009\u00b1\u20095\u2009kg) were divided into two groups; BSD (<jats:italic>n<\/jats:italic>\u2009=\u200915), and sham neurologic injury (<jats:italic>n<\/jats:italic>\u2009=\u200916). Echocardiographic parameters including global circumferential strain (GCS) and global radial strain (GRS) and pulmonary artery catheter\u2010based LVSWI were simultaneously measured at 8\u2010timepoints during 24\u2010h observation. PSP was calculated as a product of GCS or GRS, and mean arterial pressure for PSP<jats:sub>circ<\/jats:sub> or PSP<jats:sub>rad<\/jats:sub>, respectively. Myocardial mitochondrial function was evaluated following 6\u2010h observation after heart transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In BSD donor hearts, PSP<jats:sub>circ<\/jats:sub> (<jats:italic>n<\/jats:italic>\u2009=\u200996, rho\u2009=\u2009.547, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) showed the best correlation with LVSWI among other echocardiographic parameters. PSP<jats:sub>circ<\/jats:sub> returned AUC of .825 to distinguish higher values of cardiomyocyte mitochondrial function (cut\u2010off point; mean value of complex 1,2 O<jats:sub>2<\/jats:sub> Flux) in post\u2010transplant hearts, which was greater than other echocardiographic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PSP<jats:sub>circ<\/jats:sub> could be used as a surrogate of catheter\u2010based LVSWI reflecting mitochondrial function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14259","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T04:16:53Z","timestamp":1717733813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3338-1984","authenticated-orcid":false,"given":"Kei","family":"Sato","sequence":"first","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise See","family":"Hoe","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"School of Pharmacy and Medical Sciences Griffith University  Southport Queensland 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M.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Anesthesia, Critical Care and Emergency Fondazione IRCCS Ca' Granda\u2014Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Ainola","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Abbate","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  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