{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:14:41Z","timestamp":1790612081554,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018853","name":"Prince Charles Hospital Foundation","doi-asserted-by":"publisher","award":["NI2021\u201020"],"award-info":[{"award-number":["NI2021\u201020"]}],"id":[{"id":"10.13039\/501100018853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008851","name":"Xenios","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Left ventricular stroke work index (LVSWI) and cardiac power index (CPI) account for the haemodynamic load of the left ventricle and are promising prognostic values in cardiogenic shock. However, accurately and non\u2010invasively measuring these parameters during veno\u2010arterial extracorporeal membrane oxygenation (V\u2010A ECMO) is challenging and potentially biased by the extracorporeal circulation. This study aimed to investigate, in an ovine model of cardiogenic shock, whether Pressure\u2010Strain Product (PSP), a novel speckle\u2010tracking echocardiography parameter, (1) can correlate with pressure\u2010volume catheter\u2010based LVSWI and CPI, and (2) can be load\u2010independent during the flow modification of V\u2010A ECMO.<\/jats:p><\/jats:sec>Methods<\/jats:title>Nine Dorset\u2010cross ewes (51\u2009\u00b1\u20094\u2009kg) were included. After cardiogenic shock was induced, full support V\u2010A ECMO (X L\/min based on 60\u2009mL\/kg\/min) commenced. At seven time points during 24\u2010h observation, echocardiographic parameters as well as pressure\u2010volume catheter\u2010based LVSWI and CPI were simultaneously measured with X and following X\u20101\u2009L\/min of ECMO flow. PSP was calculated by multiplying global circumferential strain or global radial strain, and mean arterial pressure, for PSPcirc or PSPrad, respectively.<\/jats:p><\/jats:sec>Results<\/jats:title>PSPcirc showed a stronger correlation with LVSWI (correlation coefficient, CC\u2009=\u2009.360, p<\/jats:italic>\u2009<\u2009.001) and CPI (CC\u2009=\u2009.283, p<\/jats:italic>\u2009<\u2009.001) than other echocardiographic parameters. The predictability of PSPcirc for pressure\u2010volume catheter\u2010based LVSWI (AUC .82) and CPI (AUC .80) was also higher than other echocardiographic parameters. No statistically significant differences were identified between the two ECMO flow variations in PSPcirc (p<\/jats:italic>\u2009=\u2009.558).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A novel echocardiographic parameter, PSP, may non\u2010invasively predict pressure\u2010volume catheter\u2010based LVSWI and CPI in a load\u2010independent manner in a cardiogenic shock supported by V\u2010A ECMO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14263","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T02:55:19Z","timestamp":1717815319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A novel echocardiographic parameter considering left ventricular afterload during V\u2010A ECMO support"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3338-1984","authenticated-orcid":false,"given":"Kei","family":"Sato","sequence":"first","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silver","family":"Heinsar","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland Brisbane Queensland Australia"},{"name":"Intensive Care Unit St. Andrews War Memorial Hospital Brisbane Queensland Australia"},{"name":"Department of Intensive Care North Estonia Medical Centre Tallinn 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