{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:52:41Z","timestamp":1787068361182,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), poses a significant challenge to health care systems because of its chronic nature and increasing global prevalence. Effective management of IBD requires accurate diagnostic tools and biomarkers. This systematic review and meta\u2010analysis aimed to evaluate the relationship between bilirubin concentrations and IBD activity and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search of electronic databases identified 11 studies that included 2606 subjects with IBD and 3607 healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bilirubin concentrations were significantly lower in subjects with IBD when compared to controls (SMD\u2009=\u2009\u22120.96, 95% CI \u22121.21 to \u22120.70;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Although substantial heterogeneity was observed, sensitivity analysis confirmed the robustness of the results. Publication bias was detected, but subgroup analyses did not significantly alter the results. Meta\u2010regression showed that age was a significant factor influencing the association between bilirubin concentrations and IBD. Subgroup analyses showed a more pronounced reduction in bilirubin concentrations in subjects with CD than those with UC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study supports the potential utility of bilirubin as a biomarker in IBD, emphasizing the need for further research to validate its clinical significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.14281","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:45:01Z","timestamp":1720226701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The association between bilirubin concentrations and inflammatory bowel disease: Insights from a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4423-9745","authenticated-orcid":false,"given":"Stefano","family":"Zoroddu","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6030-2583","authenticated-orcid":false,"given":"Biagio","family":"Di\u00a0Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-6056","authenticated-orcid":false,"given":"Panagiotis","family":"Paliogiannis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Pharmacy University of Sassari  Sassari Italy"},{"name":"Anatomic Pathology and Histology Unit University Hospital (AOU) of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8699-1412","authenticated-orcid":false,"given":"Arduino A.","family":"Mangoni","sequence":"additional","affiliation":[{"name":"Discipline of Clinical Pharmacology, College of Medicine and Public Health Flinders University  Bedford Park South Australia Australia"},{"name":"Department of Clinical Pharmacology, Flinders Medical Centre Southern Adelaide Local Health Network  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-4907","authenticated-orcid":false,"given":"Ciriaco","family":"Carru","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari  Sassari Italy"},{"name":"Medical Oncology Unit University Hospital (AOU) of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8396-0968","authenticated-orcid":false,"given":"Angelo","family":"Zinellu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.1.79-94.2002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS232012445"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/UEG2.12317"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.41120"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.25122\/JML-2018-0075"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4253\/WJGE.V12.I12.504"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/ALMED-2021-0047"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/BIOMEDICINES10030696"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2021.654808"},{"key":"e_1_2_11_11_1","unstructured":"CohenJ.Statistical Power Analysis for the Behavioral Sciences Google Libri. 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