{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:48:57Z","timestamp":1792190937630,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical practice guidelines for patients with chronic kidney disease (CKD) recommend regular monitoring and management of kidney function and CKD risk factors. However, the majority of patients with stage 3 CKD lack a diagnosis code, and data on the implementation of these recommendations in the real world are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the implementation of guideline\u2010directed monitoring and management practices in the real world in patients with stage 3 CKD without a recorded diagnosis code.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>REVEAL\u2010CKD (NCT04847531) is a multinational, observational study of patients with stage 3 CKD. Eligible patients had \u22652 consecutive estimated glomerular filtration rate (eGFR) measurements indicative of stage 3 CKD recorded &gt;90 and \u2264730\u2009days apart, lacked an International Classification of Diseases 9\/10 diagnosis code corresponding to CKD any time before and up to 6\u2009months after the second eGFR measurement. Testing of key measures of care quality were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 435,971 patients from 9 countries. In all countries, the prevalence of urinary albumin\u2013creatinine ratio and albuminuria testing was low. Angiotensin\u2010converting enzyme inhibitor, angiotensin receptor blocker and statin prescriptions were highly variable, and sodium\u2013glucose cotransporter\u20102 inhibitor prescriptions remained below 21%. Blood pressure measurements were recorded in 20.2%\u201389.9% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, a large proportion of patients with evidence of stage 3 CKD did not receive recommended, guideline\u2010directed monitoring and management. The variability in standard of care among countries demonstrates a clear opportunity to improve monitoring and management of these patients, most likely improving long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.14282","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T09:58:11Z","timestamp":1721296691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Suboptimal monitoring and management in patients with unrecorded stage 3 chronic kidney disease in real\u2010world settings: Insights from\n                    <scp>REVEAL<\/scp>\n                    \u2010\n                    <scp>CKD<\/scp>"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-6370","authenticated-orcid":false,"given":"Navdeep","family":"Tangri","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian S.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Cardiovascular, Renal and Metabolism Epidemiology BioPharmaceuticals Medical, AstraZeneca  Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Arnold","sequence":"additional","affiliation":[{"name":"Real World Evidence Data &amp; Analytics BioPharmaceuticals Medical, AstraZeneca  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Barone","sequence":"additional","affiliation":[{"name":"Global Medical Affairs BioPharmaceuticals Medical, AstraZeneca  Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cebri\u00e1n","sequence":"additional","affiliation":[{"name":"Primary Care Center Cartagena Casco  Cartagena Murcia Spain"},{"name":"Biomedical Research 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