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Here, we aimed to determine whether body composition and physical performance could be prognostic factors in non\u2010small cell lung cancer (NSCLC) patients. Moreover, we performed an exploratory approach to determine whether plasma samples from NSCLC patients could directly affect metabolic and structural phenotypes in primary muscle cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study included 55 metastatic NSCLC patients and seven age\u2010matched control subjects. Assessments included physical performance, body composition, quality of life and overall survival rate. Plasma samples from a sub cohort of 18 patients were collected for exploratory studies in cell culture and metabolomic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a higher survival rate in NSCLC patients with high performance in the timed up\u2010and\u2010go (+320%; <jats:italic>p<\/jats:italic>\u2009=\u2009.007), sit\u2010to\u2010stand (+256%; <jats:italic>p<\/jats:italic>\u2009=\u2009.01) and six\u2010minute walking (+323%; <jats:italic>p<\/jats:italic>\u2009=\u2009.002) tests when compared to NSCLC patients with low physical performance. There was no significant association for similar analysis with body composition measurements (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). Primary human myotubes incubated with plasma from NSCLC patients with low physical performance had impaired oxygen consumption rate (\u221254.2%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) and cell proliferation (\u221244.9%; <jats:italic>p<\/jats:italic>\u2009=\u2009.007). An unbiased metabolomic analysis revealed a list of specific metabolites differentially expressed in the plasma of NSCLC patients with low physical performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These novel findings indicate that physical performance is a prognostic factor for overall survival in NSCLC patients and provide novel insights into circulating factors that could impair skeletal muscle metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14288","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T13:10:11Z","timestamp":1721999411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Physical performance and plasma metabolic profile as potential prognostic factors in metastatic lung cancer patients"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8796-0025","authenticated-orcid":false,"given":"Willian","family":"das\u00a0Neves","sequence":"first","affiliation":[{"name":"Faculdade de Medicina, Instituto do Cancer do Estado de Sao Paulo ICESP, Hospital das Cl\u00ednicas HCFMUSP, Universidade de Sao Paulo  Sao Paulo Brazil"},{"name":"Center for Genomic Medicine Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-9689","authenticated-orcid":false,"given":"Christiano R. R.","family":"Alves","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School, Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"School of Physical Education and Sport University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Instituto do Cancer do Estado de Sao Paulo ICESP, Hospital das Cl\u00ednicas HCFMUSP, Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Janieire N. N.","family":"Alves","sequence":"additional","affiliation":[{"name":"Heart Institute, School of Medicine University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Deik","sequence":"additional","affiliation":[{"name":"Metabolomics Platform Broad Institute of MIT and Harvard  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Pierce","sequence":"additional","affiliation":[{"name":"Metabolomics Platform Broad Institute of MIT and Harvard  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Dennis","sequence":"additional","affiliation":[{"name":"Metabolomics Platform Broad Institute of MIT and Harvard  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Buckley","sequence":"additional","affiliation":[{"name":"Metabolomics Platform Broad Institute of MIT and Harvard  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clary B.","family":"Clish","sequence":"additional","affiliation":[{"name":"Metabolomics Platform Broad Institute of MIT and Harvard  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Swoboda","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Harvard Medical School, Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia C.","family":"Brum","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"de Castro\u00a0Junior","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Instituto do Cancer do Estado de Sao Paulo ICESP, Hospital das Cl\u00ednicas HCFMUSP, Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000678"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3934\/medsci.2022016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011954"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2008.052589"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1462"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/20503121231214650"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2534-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2022.971295"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.6911"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91276-2"},{"key":"e_1_2_9_14_1","volume-title":"The EORTC QLQ\u2010C30 Scoring Manual","author":"Scott NW","year":"2008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28050291"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2016.09.010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00744.2004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2114\/jpa2.28.123"},{"key":"e_1_2_9_21_1","first-page":"1","volume-title":"A Simple Field Test for The Assessment Of Physical Fitness. 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