{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:06:29Z","timestamp":1782295589654,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00607"],"award-info":[{"award-number":["PI21\/00607"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of chronic oral anticoagulant (OACs) use on long\u2010term post\u2010discharge outcomes after coronavirus disease 2019 (COVID\u201019) hospitalisation remains unclear. Herein, we compared clinical outcomes up to 2\u2010years after COVID\u201019 hospitalisation between patients on vitamin K antagonists (VKAs), direct\u2010acting OACs (DOACs) and no OAC therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from TriNetX, a global federated health research network, were used. Adult patients on VKAs, DOACs or no OAC therapy at diagnosis of COVID\u201019 between 20 January 2020 and 31 December 2021, who were hospitalised for COVID\u201019, were included. The primary outcomes were all\u2010cause mortality, ischaemic stroke\/transient ischaemic attack (TIA)\/systemic embolism (SE) and the composite of intracranial haemorrhage (ICH)\/gastrointestinal bleeding, at 2\u2009years after COVID\u201019 hospitalisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 110,834 patients with COVID\u201019. Following propensity score matching (PSM), we identified a decreased mortality risk in DOAC\u2010treated patients compared to the no OAC cohort (RR .808, 95% CI .751\u2013.870). A higher risk of ischaemic stroke\/TIA\/SE was observed in VKA users compared to DOAC users (RR 1.100, 95% CI 1.020\u20131.220) and in VKA users compared to patients not taking OAC (RR 1.400, 95% CI 1.140\u20131.720). VKA use was associated with a greater risk of ICH\/gastrointestinal bleeding than DOAC users (RR 1.198, 95% CI 1.066\u20131.347), while DOAC users had a lower risk compared to no OAC\u2010treated patients (RR .840, 95% CI .754\u2013.936).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>COVID\u201019 patients taking prior DOACs were associated with lower long\u2010term mortality risk and ICH\/gastrointestinal bleeding than patients not taking OAC. Compared to patients on DOACs, VKA users were associated with higher risks of mortality, ischaemic stroke\/TIA\/SE and ICH\/gastrointestinal bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14299","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T10:01:06Z","timestamp":1722938466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of prior oral anticoagulation therapies on post\u2010discharge outcomes after <scp>COVID<\/scp>\u201019: Results from a\u00a0global federated health network analysis"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0492-6241","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Rivera\u2010Caravaca","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital  Liverpool UK"},{"name":"Faculty of Nursing University of Murcia  Murcia Spain"},{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), CIBERCV, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Frost","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), CIBERCV, University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. 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