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Herein, we aimed to delineate baseline characteristics of ST\u2010segment elevation myocardial infarction (STEMI) and non\u2010ST\u2010segment elevation ACS (NSTE\u2010ACS) patients stratified by initial BT and to assess its predictive utility towards major adverse cardiovascular events (MACE) after the index ACS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2012 until 2017, a total of 1044 ACS patients, 517 with STEMI and 527 with NSTE\u2010ACS, were prospectively recruited at the University Hospital Zurich. BT was measured by digital tympanic thermometer along with high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) and cardiac troponin\u2010T (hs\u2010cTnT) levels prior to coronary angiography. Patients were stratified according to initial BT and uni\u2010 and multivariable regression models were fit to assess associations of BT with future MACE risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among patients with STEMI, BT was not predictive of 1\u2010year MACE, but a <jats:italic>U<\/jats:italic>\u2010shaped relationship between BT and MACE risk was noted in those with NSTE\u2010ACS (<jats:italic>p<\/jats:italic>\u2009=\u2009.029), translating into a 2.4\u2010fold (HR, 2.44, 95% CI, 1.16\u20135.16) increased 1\u2010year MACE risk in those with BT &gt;36.8\u00b0C (reference: 36.6\u201336.8\u00b0C). Results remained robust in multivariable\u2010adjusted analyses accounting for sex, age, diabetes, renal function and hs\u2010cTnT. However, when introducing hs\u2010CRP, the BT\u2010MACE association did not prevail.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In prospectively recruited patients with ACS, initial BT shows a <jats:italic>U<\/jats:italic>\u2010shaped relationship with 1\u2010year MACE risk among those with NSTE\u2010ACS, but not in those with STEMI. BT is a broadly available low\u2010cost marker to identify ACS patients with high inflammatory burden, at high risk for recurrent ischaemic events, and thus potentially suitable for an anti\u2010inflammatory intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Registration<\/jats:title><jats:p>ClinicalTrials.gov Identifier: NCT01000701.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14314","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T04:08:28Z","timestamp":1727755708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Body temperature, systemic inflammation and risk of adverse events in patients with acute coronary syndromes"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5847-188X","authenticated-orcid":false,"given":"Jan Gerrit","family":"van der Stouwe","sequence":"first","affiliation":[{"name":"University Heart Center, University 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