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Through non\u2010invasive imaging modalities such as retinal fundus photography, early retinal microvascular alterations indicative of CKD progression can be detected, enabling timely intervention and risk stratification. However, the conclusions drawn from the review primarily demonstrate a strong or independent association between glaucoma or retinopathy and CKD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusion<\/jats:title><jats:p>Multiple shared pathophysiological events have been implicated in the pathogenesis in the alterations at eye and kidney including renin\u2010angiotensin\u2010aldosterone system. Patients with CKD are more likely to experience glaucoma, age\u2010related macular degeneration, cataracts, uremic optic neuropathy and retinopathy. To establish the role of ocular manifestations in predicting CKD progression, it is crucial to address the limitations of correlation and explore the underlying causality with further research on common disease pathogenesis. Additionally, specific methods for risk stratification based on retinal changes, the effectiveness of timely interventions, and the development of predictive tools combining ocular and renal data are of utmost importance research topics to enlighten the bidirectional causality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14324","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T10:45:05Z","timestamp":1727433905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unveiling the intricacies of chronic kidney disease: From ocular manifestations to therapeutic frontiers"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1297-0675","authenticated-orcid":false,"given":"Mehmet","family":"Kanbay","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Koc University School of Medicine  Istanbul 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