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Pharmacotherapies targeting significant weight reduction may have beneficial effects on such comorbidities, though such therapeutic options are highly limited. In this narrative review, we aim to evaluate current knowledge regarding dual agonist therapies and potential implications for managing fatty kidney and chronic kidney disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusion<\/jats:title><jats:p>Glucagon\u2010like peptide\u20101 agonists and sodium\u2010glucose cotransporter\u20102 inhibitors are two novel classes of glucose\u2010lowering medications with potential implications and beneficiary effects on renal outcomes, including estimated glomerular filtration rate, albuminuria and chronic kidney disease progression. Recently, dual agonist therapies targeting glucagon\u2010like peptide\u20101 and glucagon receptors, namely survodutide and cotadutide, have been evaluated in managing metabolically associated fatty liver disease, a well\u2010established example of visceral obesity. Fatty kidney is another novel concept implicated in the pathophysiology of chronic kidney disease among patients with visceral obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14330","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T06:30:31Z","timestamp":1728887431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Glucagon and glucagon\u2010like peptide\u20101 dual agonist therapy: A possible future towards fatty kidney disease"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1297-0675","authenticated-orcid":false,"given":"Mehmet","family":"Kanbay","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology Koc University School of Medicine  Istanbul 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