{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:44:24Z","timestamp":1791348264439,"version":"4.3.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["101095413"],"award-info":[{"award-number":["101095413"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ceramide and phosphatidylcholine lipids\u2010based risk score (CERT2) has shown a strong prognostic value in predicting cardiovascular (CV) events in patients with ischemic heart disease. This study aimed to investigate the prognostic value of CERT2 risk score in patients with heart failure (HF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current study combines data for 4234 subjects from the COMMANDER\u2010HF trial and 1227 subjects from the GISSI\u2010HF trial, which enrolled patients with a history of HF. The CERT2 risk score was calculated for all the participants as previously described. The primary outcome was CV death, but all\u2010cause death and major adverse CV events (three\u2010point MACE) were analysed as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjustment for established CV risk factors and potential confounders, patients with the highest CERT2 risk category remained at almost three\u2010fold higher risk of CV death (COMMANDER\u2010HF: HR 2.80, 95% CI 2.18\u20133.60, GISSI\u2010HF: 2.84, 95% CI 1.70\u20134.74), all\u2010cause death (COMMANDER\u2010HF: HR 2.97, 95% CI 2.36\u20133.75, GISSI\u2010HF: 2.83, 95% CI 1.83\u20134.38) and MACE (COMMANDER\u2010HF: HR 2.73, 95% CI 2.20\u20133.38, GISSI\u2010HF: 2.67, 95% CI 1.67\u20134.26) compared to those with the lowest CERT2 risk category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CERT2 risk score is strongly associated with an increased risk of CV death, all\u2010cause death and MACE in patients with HF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.14359","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T08:06:01Z","timestamp":1732349161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ceramide and phosphatidylcholine lipids\u2010based risk score predicts major cardiovascular outcomes in patients with heart failure"],"prefix":"10.1111","volume":"55","author":[{"given":"Angelika","family":"Witoslawska","sequence":"first","affiliation":[{"name":"Finnish Cardiovascular Research Center University of Tampere  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-6899","authenticated-orcid":false,"given":"Jennifer M. T. A.","family":"Meessen","sequence":"additional","affiliation":[{"name":"Department of Acute Brain and Cardiovascular Injury Institute for Pharmacological Research Mario Negri IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Hilvo","sequence":"additional","affiliation":[{"name":"Zora Biosciences Oy  Espoo Finland"},{"name":"VTT Technical Research Centre of Finland Ltd.  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Jylh\u00e4","sequence":"additional","affiliation":[{"name":"Zora Biosciences Oy  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[{"name":"Centre d'Investigation Clinique Plurith\u00e9mathique Pierre Drouin &amp; D\u00e9partement de Cardiologie, Institut Lorrain du Coeur et des Vaisseaux CHU de Nancy  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6254-8337","authenticated-orcid":false,"given":"Marianna","family":"Cerrato","sequence":"additional","affiliation":[{"name":"Department of Acute Brain and Cardiovascular Injury Institute for Pharmacological Research Mario Negri IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[{"name":"Centre d'Investigation Clinique Plurith\u00e9mathique Pierre Drouin &amp; 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