{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:30:09Z","timestamp":1790620209277,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antibody\u2010drug conjugates are novel effective therapies for metastatic breast cancer. Nevertheless, their toxicity profile can significantly affect patients' quality of life over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a systematic review and meta\u2010analysis of randomized controlled trials of antibody\u2010drug conjugates currently approved for the treatment of metastatic breast cancer [trastuzumab\u2010emtansine (T\u2010DM1), trastuzumab deruxtecan (T\u2010DXd) and sacituzumab\u2010govitecan (SG)] versus standard therapy to evaluate the risk of adverse events, discontinuation rate due to toxicity, impact on quality of life according to EORTC QLQ\u2010C30 scale and subdomains. Relative risks (RR) and hazard ratios (HR) with 95% CIs were calculated using random effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine trials with a total of 5753 patients were included. The most common adverse events of any grade for T\u2010DM1 included thrombocytopenia (RR 7.14, 95% CI 4.13\u201312.36) and increased alanine\u2010transaminase (ALT)\u00a0(RR 2.04, 95% CI 1.43\u20132.91), for T\u2010DXd were nausea (RR 2.39, 95% CI 1.90\u20133.00) and anemia (RR 1.55, 95% CI 1.27\u20131.90), while for SG were neutropenia (RR 1.30, 95% CI 1.14\u20131.49), diarrhea (RR 3.62, 95% CI 2.97\u20134.42) and nausea (RR1.90, 95% CI 1.65\u20132.19). Severe adverse events such as interstitial lung disease and left ventricular dysfunction were peculiar of T\u2010DXd. Antibody\u2010drug conjugates significantly delayed clinical deterioration of global health status by EORTC QLQ\u2010C30 (HR .71, 95% CI .59\u2013.86), physical, emotional and social functioning, pain and fatigue symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta\u2010analysis offers consolidated data on adverse events associated with antibody\u2010drug conjugates and their effects on patients' quality of life, emphasizing differences based on the specific agent. These findings underscore the critical need for effective strategies to prevent, diagnose and manage these toxicities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70001","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T04:07:00Z","timestamp":1739419620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Adverse events and impact on quality of life of antibody\u2010drug conjugates in the treatment of metastatic breast cancer: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-120X","authenticated-orcid":false,"given":"Marta","family":"Perachino","sequence":"first","affiliation":[{"name":"U.O. 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Clinica di Oncologia Medica IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Arecco","sequence":"additional","affiliation":[{"name":"U.O. Clinica di Oncologia Medica IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6150-5895","authenticated-orcid":false,"given":"Simone","family":"Nardin","sequence":"additional","affiliation":[{"name":"U.O. 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