{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:42:39Z","timestamp":1790358159973,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent evidence suggests that Alzheimer's amyloid\u2010beta (1\u201040) (\u0391\u03b21\u201040), an emerging biomarker of cardiovascular disease, may be involved in the heart\u2010brain\u2010renal axis. We aimed to comprehensively explore the association between circulating A\u03b21\u201040 levels and renal function and its clinical relevance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutively recruited subjects in the Athens Angiometabolic Registry with measured A\u03b21\u201040 plasma levels (<jats:italic>n<\/jats:italic>\u2009=\u2009811) were analysed. \u0391\u03b21\u201040 was measured by enzyme\u2010linked immunosorbent assay and glomerular filtration rate (GFR) was calculated using the abbreviated four\u2010variable Modification of Diet in Renal Disease (MDRD) formula. All\u2010cause mortality was the main clinical endpoint across a median follow\u2010up of 47\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cross\u2010sectionally, a bidirectional association between \u0391\u03b21\u201040 [adjusted odds ratio (adjOR)\u2009=\u20093.67 for highest tertile of \u0391\u03b21\u201040 and chronic kidney disease (CKD) stage \u22653, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001] and CKD stage \u22653 (adjOR\u2009=\u20093.52 for association with highest A\u03b21\u201040 tertile, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) was observed. Longitudinally, increased \u0391\u03b21\u201040 at baseline was associated with decline in renal function at follow\u2010up (adjOR for CKD stage \u22653\u2009=\u20092.26, <jats:italic>p<\/jats:italic>\u2009=\u2009.033). Similarly, longitudinal changes in A\u03b21\u201040 were inversely associated with changes in GFR (OR\u2009=\u2009.77 per 1 SD increase in A\u03b21\u201040, <jats:italic>p<\/jats:italic>\u2009=\u2009.006). A\u03b21\u201040 was associated with all\u2010cause mortality, independently of traditional risk factors (hazard ratio\u2009=\u20091.20 per 1 SD increase in A\u03b21\u201040, <jats:italic>p<\/jats:italic>\u2009=\u2009.016). An indirect effect of GFR on the association between A\u03b21\u201040 and mortality (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) with an estimated indirect\u2010to\u2010total effect ratio of .334, but not of \u0391\u03b21\u201040 on GFR with mortality, was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a population with a wide range of GFR, we found a bidirectional association between \u0391\u03b21\u201040 levels and renal function. The association of \u0391\u03b21\u201040 with all\u2010cause mortality was partly mediated by lower GFR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.70006","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:41:14Z","timestamp":1741732874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Circulating amyloid beta 1\u201040 peptide as an associate of renal function decline"],"prefix":"10.1111","volume":"55","author":[{"given":"Georgios","family":"Mavraganis","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics, Alexandra Hospital National and Kapodistrian University of Athens Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7661-5253","authenticated-orcid":false,"given":"Georgios","family":"Georgiopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical 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