{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:29:17Z","timestamp":1769275757987,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100015098","name":"Seoul Metropolitan Government Seoul National University Boramae Medical Center","doi-asserted-by":"publisher","award":["04\u20102023\u20100002"],"award-info":[{"award-number":["04\u20102023\u20100002"]}],"id":[{"id":"10.13039\/501100015098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fibulin\u20101, an extracellular matrix protein, is a potential biomarker for cardiovascular disease, but its association with target organ damage (TOD) in high\u2010risk patients remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively analysed 330 patients undergoing invasive coronary angiography (ICA) (mean age, 64.7\u2009\u00b1\u200910.7\u2009years; female, 37.9%). Blood samples obtained just before invasive coronary angiography (ICA) were stored for subsequent measurement of fibulin\u20101 levels using an enzyme\u2010linked immunosorbent assay. During index admission, eight TOD parameters (obstructive coronary artery disease, impaired kidney function, increased arterial stiffness, left ventricular hypertrophy, left ventricular diastolic dysfunction and arterial occlusive disease of peripheral arteries) were assessed. Long\u2010term clinical follow\u2010up data on major adverse cardiovascular events (MACE) were also collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fibulin\u20101 levels were significantly higher in patients with multiple TOD compared to those without (506\u2009\u00b1\u2009229 vs. 354\u2009\u00b1\u2009148 mcg\/mL; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Serum fibulin\u20101 levels increased proportionally with the number of TODs (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Multivariable analyses identified that each 100 mcg\/mL increase in serum fibulin\u20101 level was significantly associated with an increased risk of multiple TOD, even after adjustment for potential confounders (odds ratio: 1.29\u20131.45; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Similarly, each 100 mcg\/mL increase in serum fibulin\u20101 level was associated with a 29% higher incidence of MACE (95% confidence interval, 1.14\u20131.46; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fibulin\u20101 is strongly associated with the extent of TOD and may serve as a useful biomarker for risk stratification in high\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.70039","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T17:12:36Z","timestamp":1743268356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum fibulin\u20101 levels and target organ damage in patients at high cardiovascular risk: A prospective observational study"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-1472","authenticated-orcid":false,"given":"Hack\u2010Lyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government\u2010Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Pyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Seoul Metropolitan Government\u2010Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeonghwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Seoul Metropolitan 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