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Key gaps include insufficient long\u2010term data on obesity trends, the inadequacy of body mass index (BMI) as a sole diagnostic measure, and insufficient recognition of phenotypic diversity in obesity\u2010related cardiometabolic risks. Moreover, the socio\u2010economic drivers of obesity and its transition across phenotypes remain poorly understood.<\/jats:p><\/jats:sec>Results<\/jats:title>The syndemic nature of obesity, exacerbated by globalization and environmental changes, necessitates a holistic approach integrating global frameworks and community\u2010level interventions. This statement advocates for leveraging emerging technologies, such as artificial intelligence, to refine predictive models and address phenotypic variability. It underscores the importance of collaborative efforts among scientists, policymakers, and stakeholders to create tailored interventions and enduring policies.<\/jats:p><\/jats:sec>Discussion<\/jats:title>The consensus highlights the need for harmonizing anthropometric and biochemical markers, fostering inclusive public health narratives and combating stigma associated with obesity. By addressing these gaps, this initiative aims to advance research, improve prevention strategies and optimize care delivery for people living with obesity.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This collaborative effort marks a decisive step towards mitigating the obesity epidemic and its profound impact on global health systems. Ultimately, obesity should be considered as being largely the consequence of a socio\u2010economic model not compatible with optimal human health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.70059","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T07:39:37Z","timestamp":1747294777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-4078","authenticated-orcid":false,"given":"Federico","family":"Carbone","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Genoa Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Despr\u00e9s","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec \u2013 Universit\u00e9 Laval Qu\u00e9bec Qu\u00e9bec Canada"},{"name":"VITAM \u2013 Centre de Recherche en sant\u00e9 Durable Centre int\u00e9gr\u00e9 Universitaire de sant\u00e9 et de Services Sociaux de la Capitale\u2010Nationale Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3118-6859","authenticated-orcid":false,"given":"John P. 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