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Recent advancements in molecular imaging, particularly with Positron Emission Tomography (PET) using radiolabelled Prostate\u2010Specific Membrane Antigen (PSMA) tracers, have shown significant improvements in enhancing prostate cancer detection. PSMA PET, when combined with magnetic resonance imaging (MRI) in hybrid PET\/MRI systems, provides improved sensitivity and specificity, enabling more precise localization of clinically significant prostate cancer (csPCa) lesions. This narrative review explores the evolving role of PET\/CT and PET\/MRI\u2010guided prostate biopsy. We examine the integration of PET with MRI for the detection of prostate cancer, highlighting key studies that have demonstrated improved diagnostic outcomes. Additionally, we discuss the current limitations, including the high costs and longer scan times associated with PET\/MRI, as well as the challenges in data interpretation. The review also considers emerging technologies, such as promising molecular probes for prostate PET imaging, such as gastrin\u2010releasing peptide receptor (GRPR) and fibroblast activation protein inhibitor (FAPI). Finally, the present work provides the clinician with a comprehensive yet concise up\u2010to\u2010date review of the literature to easily evaluate the possibilities currently offered by hybrid imaging technologies of personalized imaging\u2010guided biopsy for prostate cancer patients.<\/jats:p>","DOI":"10.1111\/eci.70062","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:26:32Z","timestamp":1745396792000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The evolving role of positron emission tomography in precision prostate cancer biopsy"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-5146","authenticated-orcid":false,"given":"Alessio","family":"Imperiale","sequence":"first","affiliation":[{"name":"Nuclear Medicine University Hospitals of Strasbourg, University of Strasbourg  Strasbourg France"},{"name":"Nuclear Medicine and 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