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The aim of this study was to analyse gastric mucosa\u2010associated microbiota in patients with obesity and nonatrophic chronic gastritis in the absence of HP infection or history of HP eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a case\u2013control study conducted at Virgen de la Victoria University Hospital in Malaga, performed in patients with severe obesity (body mass index \u226540\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) undergoing sleeve gastrectomy, without HP infection and no history of HP eradication. Gastric biopsy specimens were collected at surgery and were analysed by 16S rRNA sequencing. Participants were divided into two groups according to the histological evaluation: nonatrophic chronic gastritis and nongastritis. An exploratory prospective analysis to determine the influence of gastritis on short\u2010term outcomes after surgery was also performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010seven participants (38 in the gastritis and 29 in the nongastritis group) were included. A lower alpha diversity (evenness and Shannon diversity indexes) and beta diversity (weighted Unifrac distance) were shown in the gastritis group. Higher relative abundances in the families\n                      <jats:italic>Micrococcaceae<\/jats:italic>\n                      ,\n                      <jats:italic>Streptococcaceae<\/jats:italic>\n                      and\n                      <jats:italic>Leuconostocaceae<\/jats:italic>\n                      and the genera\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      ,\n                      <jats:italic>Weissella<\/jats:italic>\n                      and\n                      <jats:italic>Cryptobacterium<\/jats:italic>\n                      were observed in the gastritis group, compared with the nongastritis group. An enrichment in pathways involved in toluene degradation, heterolactic fermentation and secondary metabolites biosynthesis, such as ergothioneine and terpenoids, was found in the gastritis group. Also, higher total cholesterol levels 1\u2009year after the surgery were observed in the gastritis group compared with the nongastritis group, although no within\u2010group differences from baseline to 1\u2009year were detected in this parameter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest a relationship between the gastric microbiome and nonatrophic chronic gastritis in obesity, beyond HP infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70085","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:07:54Z","timestamp":1750147674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gastric microbiota\u2010specific signatures in adults with obesity and\n                    <i>Helicobacter pylori<\/i>\n                    \u2010negative gastritis"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9761-6888","authenticated-orcid":false,"given":"Jos\u00e9 Ignacio","family":"Mart\u00ednez\u2010Montoro","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010Plataforma en Nanomedicina (IBIMA\u2010Plataforma Bionand)  M\u00e1laga Spain"},{"name":"Department of Endocrinology and Nutrition Virgen de la Victoria University Hospital  M\u00e1laga Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de la Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Sancho\u2010Mar\u00edn","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010Plataforma en Nanomedicina (IBIMA\u2010Plataforma Bionand)  M\u00e1laga Spain"},{"name":"Department of Endocrinology and Nutrition Virgen de la Victoria University Hospital  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Oca\u00f1a\u2010Wilhelmi","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010Plataforma en Nanomedicina (IBIMA\u2010Plataforma Bionand)  M\u00e1laga Spain"},{"name":"Department of General and Digestive Surgery Virgen de la Victoria University Hospital  M\u00e1laga Spain"},{"name":"Department of Surgical Specialties, Biochemistry, and Immunology University of M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Arranz\u2010Salas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010Plataforma en Nanomedicina (IBIMA\u2010Plataforma Bionand)  M\u00e1laga Spain"},{"name":"Department of Anatomical 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