{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:49:18Z","timestamp":1784371758360,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009045","name":"Uniwersytet Jagiello\u0144ski Collegium Medicum","doi-asserted-by":"publisher","award":["K\/ZDS\/002936"],"award-info":[{"award-number":["K\/ZDS\/002936"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is associated with a prothrombotic state. We investigated whether factor VIIa\u2010antithrombin (FVIIa\u2010AT) complexes, a marker of tissue factor (TF) exposure, are associated with thromboembolic events in AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In 224 nonvalvular AF patients (66% men, median age 69\u2009years, median CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      VASc score 4), 71% on direct oral anticoagulants, we measured FVIIa\u2010AT complexes, along with endogenous thrombin potential (ETP), von Willebrand factor (VWF) and 8\u2010isoprostane, reflecting oxidative stress. During a median follow\u2010up of 53 [interquartile range, IQR 47\u201357] months, we recorded a composite endpoint: ischemic stroke, systemic thromboembolism or cardiovascular (CV) death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FVIIa\u2010AT complexes (median 145 [IQR 125\u2013170] pM) were higher in patients with permanent AF (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), vascular disease (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02), previous stroke (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and smoking (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006) as compared with patients without these comorbidities. FVIIa\u2010AT correlated with NT\u2010proBNP (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.022) and ETP (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). During follow\u2010up, the composite endpoint was recorded in 30 patients (13.4%, 3.0% per year) including 20 with ischemic stroke (8.9%, 2.0% per year, respectively). Patients with the composite endpoint had 29.2% higher baseline FVIIa\u2010AT complexes compared with the remainder. Patients with FVIIa\u2010AT complexes in the top quartile (&gt;170 pM) had an increased risk of the composite endpoint (HR 12.0, 95% CI 5.2\u201328.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). FVIIa\u2010AT complexes, along with VWF, remained independently associated with the composite endpoint.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study is the first to show that high plasma FVIIa\u2010AT complexes are independently associated with thromboembolic events or CV death in AF, suggesting the need for more potent anticoagulation to suppress the residual TF\u2010mediated coagulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70091","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T10:49:19Z","timestamp":1750330159000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elevated factor VIIa\u2014antithrombin complexes are associated with stroke or cardiovascular death in patients with atrial fibrillation"],"prefix":"10.1111","volume":"55","author":[{"given":"El\u017cbieta","family":"Szczygie\u0142\u2010Pilut","sequence":"first","affiliation":[{"name":"Department of Neurology St John Paul II Hospital  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"B\u0142a\u017c","sequence":"additional","affiliation":[{"name":"Department of Neurology St John Paul II Hospital  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Pociask","sequence":"additional","affiliation":[{"name":"Department of Biocybernetics and Biomedical Engineering AGH University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Paszek","sequence":"additional","affiliation":[{"name":"Clinical Department of Interventional Cardiology St John Paul II Hospital  Krak\u00f3w Poland"},{"name":"Department of Thromboembolic Disorders, Institute of 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