{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:51:45Z","timestamp":1790880705016,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The high\u2010density lipoprotein (HDL) and the phospholipid transfer protein (PLTP) have been demonstrated to enhance endotoxin elimination and inactivation in animal models of sepsis. This study aimed to confirm such a role in patients presenting with abdominal sepsis undergoing emergent surgery and explore the relationships between HDL, PLTP and the lipopolysaccharide (LPS) burden (mass and activity).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients operated for abdominal sepsis were prospectively included in the study. Blood samples were obtained before surgery, at the end of the operation (H0), 4\u2009h (H4) and 24\u2009h (H24) later. Peritoneal fluid was also sampled. HDL cholesterol, LDL cholesterol, PLTP activity, LPS mass and activity were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010seven patients were included. At H0, LPS mass was mostly measured in the lipoprotein fractions (46% [23; 58] in HDL and 36% [29; 54] in LDL). Overall, LPS mass and LPS activity did not decrease in the 24\u2009h following admission to the ICU. Both HDLc concentrations and PLTP activity were associated with increased H4\u2010LPS elimination (drop in LPS concentration, \u22123% [\u221226;10] vs. 29% [13;52],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01 and \u22122% [\u221215;10] vs. 20% [8:52],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03, respectively). Increased H4\u2010LPS elimination was associated with reduced inflammation (plasma cytokine concentration) and mortality. High HDL cholesterol was associated with reduced mortality but not with inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data support the role of HDL and PLTP in the elimination of LPS during human peritonitis with sepsis. Increased H4\u2010LPS elimination was associated with reduced inflammation and lower mortality.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT04126577.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eci.70099","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T08:09:32Z","timestamp":1752912572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["High\u2010density lipoproteins alleviate the endotoxin burden in patients with peritonitis and sepsis: The\n                    <scp>LIPS<\/scp>\n                    study"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2334-1487","authenticated-orcid":false,"given":"Maxime","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Dijon University Hospital  Dijon France"},{"name":"Universit\u00e9 Bourgogne Europe  Dijon France"},{"name":"Center for Translational and Molecular Medicine (CTM), INSERM UMR1231, Lipness Team  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Center for Translational and Molecular Medicine (CTM), INSERM UMR1231, Lipness Team  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Berthoud","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Dijon University Hospital  Dijon 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Molecular Medicine (CTM), INSERM UMR1231, Lipness Team  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Masson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe  Dijon France"},{"name":"Center for Translational and Molecular Medicine (CTM), INSERM UMR1231, Lipness Team  Dijon France"},{"name":"Laboratory of Clinical Chemistry Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gautier","sequence":"additional","affiliation":[{"name":"Center for Translational and Molecular Medicine (CTM), INSERM UMR1231, Lipness Team  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belaid","family":"Bouhemad","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Dijon University Hospital  Dijon France"},{"name":"Universit\u00e9 Bourgogne Europe  Dijon France"},{"name":"Center for 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