{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:50:12Z","timestamp":1789426212220,"version":"build-2803163510"},"reference-count":93,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. The human myocardium has a limited regenerative capacity, prompting the development of innovative strategies to restore cardiac function. Stem cells (SCs) and bioartificial tissues (BATs) have emerged as promising tools in regenerative cardiology for myocardial repair and functional recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This review analyzes current preclinical and clinical research focused on SC\u2010 and BAT\u2010based therapies for CR. Literature was identified through comprehensive database searches. Studies evaluating cardiomyocyte differentiation, integration into host tissue, vascularisation and electromechanical properties were selected. Emphasis was placed on therapeutic potential, safety and translational challenges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SCs, including embryonic and mesenchymal stem cells, demonstrated potential to differentiate into cardiomyocyte\u2010like cells and contribute to myocardial restoration. When combined with biomaterial scaffolds or decellularized matrices, SCs showed improved survival, structural support, and functional integration. BATs, such as engineered heart tissue, replicated native myocardial architecture and supported synchronized contraction. Despite these advances, concerns persist regarding immunogenicity, arrhythmias, and long\u2010term efficacy. Technical hurdles in large\u2010scale production and personalised application remain unresolved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SC\u2010 and BAT\u2010based therapies offer innovative avenues for repairing damaged myocardium. Their application could revolutionise treatment strategies for heart failure and post\u2010infarction remodelling. However, clinical translation requires addressing immune compatibility, arrhythmic risk and manufacturing limitations. Interdisciplinary collaboration and regulatory standardisation are essential for their future clinical adoption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.70101","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T13:05:31Z","timestamp":1753189531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Advances in regenerative cardiology: Stem cells versus bioartificial tissues"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4682-3999","authenticated-orcid":false,"given":"Jenyfer Mar\u00eda","family":"Fuentes\u2010Mendoza","sequence":"first","affiliation":[{"name":"School of Medicine Universidad Cient\u00edfica del Sur  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-1496","authenticated-orcid":false,"given":"Juan","family":"Mu\u00f1oz\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Eastern Virginia Medical School at Old Dominion University  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-1875","authenticated-orcid":false,"given":"Marcio","family":"Concepci\u00f3n\u2010Zavaleta","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad Cient\u00edfica del Sur  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-3101","authenticated-orcid":false,"given":"Luis","family":"Concepci\u00f3n\u2010Urteaga","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad Nacional de Trujillo  Trujillo Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-3727","authenticated-orcid":false,"given":"Jos\u00e9","family":"Paz\u2010Ibarra","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad Nacional Mayor de San Marcos  Lima Peru"},{"name":"Department of Endocrinology Edgardo Rebagliati Martins National Hospital  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1119-3985","authenticated-orcid":false,"given":"Roger","family":"Gonzales\u2010Valdivieso","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad Cient\u00edfica del Sur  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0437-3361","authenticated-orcid":false,"given":"Fernanda Ginebra","family":"Castillo\u2010Vel\u00e1squez","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad Cient\u00edfica del Sur  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3545-6950","authenticated-orcid":false,"given":"Angie Sof\u00eda","family":"Burgos\u2010Castillo","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad Cient\u00edfica del Sur  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5970-7876","authenticated-orcid":false,"given":"Regina","family":"Garza\u2010Boullosa","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad La Salle  Ciudad de Mexico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9129-4072","authenticated-orcid":false,"given":"Vanesa Daniela","family":"N\u00fa\u00f1ez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad Cient\u00edfica del Sur  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.01.022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12555"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1858"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2021-320131"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2023.04.018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201806050"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.05.040"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30004-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnma.2020.02.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1594"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2013.04.009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-024-01098-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2022.01.012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0077-x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10262"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0036-6"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02567-2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.01.018"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam5894"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040766"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-020-01361-7"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.117.312586"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI87491"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00540-z"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-023-01877-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-019-02163-7"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.117.310820"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1157\/13052378"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13233"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1963910"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2015.02.025"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118002"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2017_113"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102087"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.092627"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114817"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2023.12.009"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2016.0268"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.305373"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21175952"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20160097"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301980"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061420"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1344885"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.641116"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa337"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16626-9"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.724"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.33064\/iycuaa2015643597"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.32440\/ar.2022.139.01.ed01"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1394"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133073"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.727420"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.888"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.10.066"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000087450.34497.9a"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.08.010"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5340616"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13081180"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/aa8113"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.35687\/s2452-45492021003906"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2016.03.014"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115870"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.961920"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-018-0992-9"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030742"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8040522"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.circv.2022.10.006"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53531-8"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3tb00174a"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.09.013"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03690-8"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307527"},{"key":"e_1_2_9_78_1","unstructured":"ShinA.The history current status benefits and challenges of 3d printed organs. arXivorg.2022. doi:10.48550\/arXiv.2207.13212"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.18270\/rcb.v15i1.2624"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1214431"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.116.013003"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1165-5"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872019000600787"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12910-020-00482-6"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e35836"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2021.05.012"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-023-00348-z"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.881523"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.6515\/ACS.202011_36(6).20200811A"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.664592"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01309-7"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8960236"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14020131"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2412309"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.70101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:59:26Z","timestamp":1760407166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.70101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":93,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/eci.70101"],"URL":"https:\/\/doi.org\/10.1111\/eci.70101","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"2025-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70101"}}